نتایج درمانی لوسمی حاد لنفوبلاستیک با پروتکل UKCCSG: مشخصات بالینی و پیش آگهی

فتحی, افشین and پدرام, محمد and هیرادفر, امیر عطا ا... (1389) نتایج درمانی لوسمی حاد لنفوبلاستیک با پروتکل UKCCSG: مشخصات بالینی و پیش آگهی. Pakistan Journal of Medical Sciences ــ 26 (3). pp. 562-566. شاپا 1681-715X

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Official URL: http://www.pjms.com.pk/issues/julsep2010/index.htm


Results of chemotherapy by UKCCSG protocol in children with acute lymphoblastic leukemia: Clinical characteristics and outcome

English Abstract

Background: Acute lymphoblastic leukemia (ALL) represents a clonal expansion and arrest of normal lymphoid hematopoiesis. ALL remains the most common malignancy in children. The survival rate of the patients is significantly increased since the 1968s. This study was undertaken to evaluate the 5- year overall survival (OS) rates of patients with ALL in a single center in IRAN. Methods: A total of 220 children with ALL up to 15 years old who had been treated by UKCCSG protocol at the Oncology Department in Shafa Hospital from March 1997 to October 2004 were evaluated for their age, gender, as well as FAB types, presenting features, outcomes of therapy and relapse. Results: The mean age of the patients was 6.69 years (SD= 3.8, median 6 years). In this series, 123 patients (55.9%) were male. There was a complete remission induction rate of 85.5% during first induction course of therapy. 5-year overall survival was 60.9% and it was better (p=0.006) in standard risk group. Relapse rate after first remission was 23.6% and death due to relapse was more in high risk group, but it was not significant (p=0.053). There were 59(68.6%) of total deaths in induction period and 18(20.9%) after relapse. Overall infections (69.4%) were major cause of deaths in induction period. OS was better in boys, age group between (1-10 yo) and initial white blood cells count (10,000-50,000x103/mm3) but there were not significant (p=0.39, p=0.30, p=0.202, respectively). Conclusion: 5-year overall survival was 60.9% of the children with new ALL who were undergoing chemotherapy by UKCCSG protocol. High mortality rate in induction period mainly due to infections decreases 5-year overall survival in this study.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :افشین فتحی
نویسنده مسئول :محمد پدرام
Additional Information:Current Impact Factor (2010) 0.166 1-Indexed & abstracted in Science Citation Index Expanded (SCIE) by Thompson/ISI USA, Web of Science, 2-Embase/Excerpta Medica Netherlands,SCOPUS, 3-WHO IMEMR Current Contents, Index Copernicus Poland, INIS Database, CAB Abstract and Global Health UK, Pakistan Science Abstract, Registered with International Serials Data System of France, approved by the PM&DC and covered by Pakmedinet, Open-J gate India, doaj and emrmedex.com Iran
کلیدواژه ها (انگلیسی):acute lymphoblastic leukemia , UKCCSG , survival
Subjects:WH Hemic and Lymphatic System
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:2579
Deposited By: Dr Afshin Fathi
Deposited On:19 May 1390 11:33
Last Modified:12 Nov 1391 10:32

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