استفاده از MDA سرم به عنوان مارکر تشخیصی در بیماری شریان قلبی پایدار

Title

serum MDA as a diagnostics biomarker in stable coronary heart disease

English Abstract

The recent studies showed that Malondialdehyde (MDA) is the important marker of lipid peroxidation and progression of atherosclerosis is correlated with oxidative stress and can be followed up by MDA measurements. The aim of this study was to investigate relationship between MDA and lipoprotein concentrations in male patients with Coronary Artery Disease (CAD). This case control study was performed 51 male patients with angiographically confirmed CAD admitted to Shahid Madani Hospital in Tabriz city of Iran as a study group and 60 healthy males that matched in age and sex as the control group. The serum level of MDA was measured by colorimetric method using thiobarbituric acid reaction and lipid and lipoproteins concentrations were determined by standard enzymatic methods. The findings were analyzed using Pearson`s correlation test for measurement of relation between MDA with other variables and t-test statistical method for comparison in two groups. The result showed that serum concentrations of cholesterol, triglyceride, LDL-C and LDL-C/HDL-C ratio and level of MDA in patients group were higher than healthy group (p< 0.05). There was positive and significant relationship in patients group between serum MDA, triglyceride, cholesterol, LDL-C and LDL-C/HDL-C ratio, but the correlation between MDA and HDL-C was negative and meaningful (p< 0.05). No relationship was observed between MDA with BMI and age in the patients group (p>0.05). There is an increasing acceptance that oxidative modification of lipid and lipoprotein is a crucial step in the development of atherosclerosis. In view of the relationship between changes in the serum levels of lipids and lipoproteins and that of MDA in patients with CAD it was concluded that simultaneous control of both dyslipoproteinemia and lipid peroxidation may be of equal importance in prevention of CAD. The independent association of MDA levels with stable CHD indicates a possible role of these parameters as biomarkers of CHD patients.

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