سنجش آمین اکسیداز حاوی مس در بیماران مبتلا به سرطان معده

Title

Evaluation of Cu containing amine oxidase is sera of gastric cancer patients

English Abstract

Introduction: Cupper containing amine oxidase (Cu-AO) catalyzes the deamination of primary amines to corresponding aldehydes in the presence of oxygen with the subsequent release of ammonia and hydrogen peroxide. Cu-AO also is known as soluble vascular adhesion molecule-1 (sVAP-1). It has been shown that the serum level of Cu-AO changes in various cancers. Literature review showed that there was no information on Cu-AO serum concentration among Iranians as well as in gastric cancer patients. The present study was conducted with two major aims 1) determination of Cu-AO concentration in healthy people; 2) to investigate the changes of the enzyme in gastric patients compared to control. Material and method: This investigation as a case–control study included 200 healthy and GC patient volunteers referred to Aras Clinic in Imam Khomeini Hospital. Blood samples were collected and serum was separated and stored at −70 °C until ELISA examinations. Questionnaires were distributed and filled out by both patients and healthy people. Results and conclusion: Present investigation showed that there is no significant change in serum level of Cu-AO in regard to sex, age, smoking and BMI. The serum level of Cu-AO in healthy subjects was higher than values reported in other countries. Whether these finding would open new sights into etiology of high incidence of GC in Ardabil province needs further investigations. Cu-AO levels in serum show a significant decrease in GC patients in relative to controls, this decline in Cu-AO might have been used as a biomarker for gastric cancer diagnosis.

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