مطالعه مقايسه اي ارتباط بين تست CAT و Hs-CRP با ايندكس هاي SPO2 , FEV!, BODE index, و ريت تشديد دوره بيماري COPD

Title

A comparative study of the correlations of the COPD assessment test (CAT) scores and high sensitive CRP levels to SPO2, FEV1, BODE index, and exacerbation rate.

English Abstract

Background: High sensitive CRP is used as a marker of systematic inflammation in COPD. Results have shown an inverse relation between serum hs-CRP and FEV1, except for small study which did not report any correlation between hs-CRP level and FEV1. However, we hypothesize that the raised hs-CRP is not closely related to the multiple consequences of COPD. CAT is a simple questionnaire for assessing and monitoring COPD. Thus, this study was undertaken to investigate the correlations between CAT score and SPO2, FEV1, BODE index, and exacerbation rate, and compare it with the correlations to the serum hs-CRP. Method: We studied 60 patients with stable COPD and 15 normal subjects as a control group. SPO2, BODE index, pulmonary function test and exacerbation rate were determined in COPD patients. Serum level of hs-CRP was measured in all patients and the control group. Then, the CAT questionnaire was completed by patients. Results: Hs-CRP level was significantly raised in patients (p=0.005). In these patients, correlations of hs-CRP level with BODE index appeared significant (p=0.008). However, the correlation between hs-CRP with SPO2 and FEV1 did not appear significant (p=0.47, p=0.17respectively). Also, the CAT score correlations with SPO2, FEV1, BODE index, and exacerbation rate in the previous year were all found to be significant (p=0.000, p=0.000, p=0.000, p=0.017, respectively). Conclusion: We conclude that SPO2, FEV1, BODE index and exacerbation rate are more correlated with the CAT scores than with the serum level of hs-CRP in stable COPD patients. The findings of this study should be considered in management of stable COPD.

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