مقايسه تاثيرات درماني فلوتاميد خوراکی و سیپروترون در خانمها مبتلا به آکنه

عدالتخواه, حسن and پورفرضی, فرهاد and صادقی, همایون (1390) مقايسه تاثيرات درماني فلوتاميد خوراکی و سیپروترون در خانمها مبتلا به آکنه. Clinical, Cosmetic and Investigational Dermatology ــ 4 . pp. 117-121. شاپا 1178-7015

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Flutamide versus a cyproterone acetate-ethinyl estradiol combination in moderate acne: a pilot randomized clinical trial

English Abstract

Background: The use of oral flutamide is rarely investigated in acne therapy. The aim of this study was to compare the efficacy of oral flutamide with that of a cyproterone-estradiol combination in treating acne lesions. Methods: A randomized clinical trial enrolled patients with moderate acne into two equal groups to receive either oral flutamide or the cyproterone-estradiol combination for 6 months. Lesion count, Acne Severity Index, and Global Acne Grading system (GAGS) scores were used to assess improvement in acne lesions. The dichotomous measurement scale for primary endpoint assessment was defined as improvement from moderate to mild acne based on GAGS score. Patient satisfaction and dermal fat were also assessed. Intention to treat and per protocol analyses were done, reporting related effect sizes. Results: Both treatments resulted in substantial improvement in acne lesions. Although flutamide seemed to have higher efficacy, an intention to treat analysis did not find the two treatment protocols to be different. The relative risk in intention to treat analysis was 1.8 (95% confidence interval [CI] 0.89–1.6), and was 1.33 (95% CI 1.03–1.72) for the per protocol analysis. The number needed to treat for flutamide compared with the cyproterone-estradiol combination was 7.7 and 4.2 in the intention to treat and per protocol analyses, respectively. Conclusion: Flutamide appears to be more effective than a cyproterone-estradiol combination in some aspects of acne treatment, but this requires confirmation in a larger trial.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :حسن عدالتخواه
Additional Information:Indexed online: PubMed (Clin Cosmet Investig Dermatol) American Chemical Society's Chemical Abstracts Service (CAS) EMBase Scopus OAIster - The Open Access Initiative ResearchGATE scientific network Directory of Open Access Journals (DOAJ)
کلیدواژه ها (انگلیسی):acne vulgaris, flutamide, cyproterone acetate, ethinyl estradiol, androgen antagonists
Subjects:QV pharmacology
WR Dermatology
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Dermatology , Psychiatry , Neurology
ID Code:2746
Deposited By: MS Soghra Golmaghani
Deposited On:18 Aug 1390 11:08
Last Modified:28 Jan 1392 08:32

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