مقایسه ارتباط ضخامت اینتیما-مدیای کاروتیدونشانه های آزمایشگاهی و کلینیکی آترواسکلروز سیستمیک در دیابت تیپ دو

Title

Comparison carotid intimae- media thickness and clinical and laboratory markers of systemic atherosclerosis in type 2 diabetic

English Abstract

Objective :The aim of this stady was to measure carotid IMT of type 2 diabetic patients and assment its relationship with a number of clinical and laboratory markers of systemic atherosclerosis. Method: A random sample of 100 type 2 diabetic patients were enrolled the study.IMT was determined ultrasonographically by Siemens SONOLINE Sienna by using seven mega Hertz probe at six sites of carotid system on the left and right sides including common carotids, carotid bulbs, and internal carotids. data were collected and analyzed be SPSS software. Results: The sample consisted of 41 men and 59 women who were between ages of 33 and 87 years. In this study more than 80% of patients had creased IMT measurements. Most strong relationships between atherosclerosis risk factors and severity of increase in IMT were held by male sex, smoking, lack of regular exercise, severe 3 mental stress or depression, dyslipidemia and nappropriate blood glucose control ( based on Hb AIC levels), respectively. Relative severity or risk score of atherosclerosis also had a strong relationship with severity of IMT increase. Discussion: this study also highlighted the significant association between abnormal IMT and higher number of atherosclerosis risk factors. The lack of relationships between hypertension and obesity with severity of IMT increase might be attributed to extensive use of antihypertensive medications and high prevalence of obesity among type2 diabetic patients.

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