کارآزمایی بالینی دو سوکور تصادفی شده و پایلوت مصرف موضعی روغن زیتون خام در مقابل ژل پیروکسیکام در درمان استئوآرتریت زانو

بهلولی, شهاب and جستان, مارینا and نخستین روحی, بابک and محمدی, پرهام سعداله and بقایی, زهرا (1390) کارآزمایی بالینی دو سوکور تصادفی شده و پایلوت مصرف موضعی روغن زیتون خام در مقابل ژل پیروکسیکام در درمان استئوآرتریت زانو. JCR-Journal of Clinical Rheumatology ــ 18 (2). pp. 99-101. شاپا 1076-1608

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/22334264


A Pilot Double-Blinded, Randomized, Clinical Trial of Topical Virgin Olive Oil Versus Piroxicam Gel in Osteoarthritis of the Knee

English Abstract

Osteoarthritis (OA) is the most common type of arthritis, and the knee is the most common site of symptomatic OA.1 Knee OA is responsible for a higher incidence of disability than any other long-term conditions.2 Topical therapies present a therapeutic option for OA pain management. Nonsteroidal anti-inflammatory drugs (NSAIDs), salicylates, and capsaicin are currently the main topical therapies available.3 There is a need for safe and effective drugs for patients who do not respond well to conventional medical therapy. Indeed, such patients are turning increasingly to complementary/alternative medicines.4,5 One of the traditional methods for management of knee pain in some rural area of Iran is application of topical olive oil, as reported by Avicenna 6 in his 10th-century book Canon of Medicine. Although the composition of olive oil is complex, the major groups of compounds thought to contribute to its observed health benefits include oleic acid, phenolics, and squalene,7 all of which have been reported to inhibit oxidative stress.8 Researchers reported beneficial effects of olive oil on rheumatoid arthritis after oral consumption.9 In 2005, (-)-oleocanthal, the dialdehydic form of (-)-deacetoxy-ligstroside aglycone present in freshly pressed extra virgin olive oil, was shown to have properties of an NSAID.10 Although topical virgin olive oil is traditionally used in Iran in treating knee pain as an herbal medication, our survey did not find any scientific evaluation of its efficacy. Accordingly, we conducted a pilot prospective, comparative, randomized, double-blinded trial of topical virgin olive oil therapy versus piroxicam gel in the treatment of knee OA. The report was prepared as recommended by the CONSORT statement 11,12 and its elaboration on herbal interventions.13

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :شهاب بهلولی
نویسنده :مارینا جستان
نویسنده :بابک نخستین روحی
نویسنده :پرهام سعداله محمدی
نویسنده :زهرا بقایی
Additional Information:Impact Factor:1.283 Indexed in Medline PubMed and ISI , Science Citation Index Expanded , Current Contents - Clinical Medicine Index medicus
کلیدواژه ها (انگلیسی):Clinical Trial، Virgin Olive Oil ، Piroxicam، Osteoarthritis of the Knee
Subjects:QV pharmacology
WE Musculoskeletal system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:3083
Deposited By: Dr Shahab Bohlooli
Deposited On:29 Nov 1390 08:21
Last Modified:12 Dec 1397 13:40

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