داپسون به عنوان یک درمان جایگزین در کودکان مبتلا به تب مدیترانه ای فامیلی

صالح زاده, فرهاد and جهانگیری, سپیده and محمدی کلاسرلو, ایلنار (1390) داپسون به عنوان یک درمان جایگزین در کودکان مبتلا به تب مدیترانه ای فامیلی. Iranian Journal of Pediatrics ــ 22 (1). pp. 23-27. شاپا 2008-2142

Text - Published Version

Official URL: http://ijp.tums.ac.ir/index.php/ijp/article/view/1...



English Abstract

Objective: Familial Mediterranan Fever is an hereditary autoinflammatory disease that presents with recurrent febrile attacks and poly serositis. Colchicine is the only known treatment in this diease. However, nearly 5-10% of patients are resistant to colchicines. There are many different modalities in colchicine resistant patients, biologic and immunosupressive drugs being the known ones. We studied the efficacy of Dapsone as an anti inflammatory drug in children with FMF who did not tolerate colchicine well. Methods: This is a case series study in 10 patients who had FMF on the base of Tel-Hashomer criteria and did not tolerate colchicine or did not respond to it well. Patients took 2mg/kg dapsone in single dose, during 6 months. Findings In four patients episodic attacks returned after 27 days, so the drug was discontinued. One patient refused to continue the study; in five patients dapsone was taken in average for 8 months and 6 days, at least for 6 months. These five patients had no episodes of attack during the following observation. Conclusion: Dapsone could control episodic attacks of FMF in 50% of cases. It might be considered as an alternative therapy in FMF cases not responding to colchicine.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :فرهاد صالح زاده
Additional Information:Impact Factor 2010: 0.148 Indexed in:1-ISI (Citation Index Expanded) 2-Embase, Scopus 3- CINAHL , Bioline International website,Global Health Directory Open Access Journals (DOAJ), Eastern Mediterranean Index Medicus (IMMER) ,National Library for Health , Sientific Information System (SID) Iranmedex ,Magiran , EMRMedex , Genamics-JournalSeek Index Copernicus , MedBioWorld , Nutrition and Food Sciences Open J-Gate , Ulrich database ,Electronic Journals Index (SJSU) , Electronic Journals Library (EZB)
کلیدواژه ها (انگلیسی):Dapsone; Familial Mediterranan Fever; Periodic Fever; Children
Subjects:WB Practice of Medicine
WE Musculoskeletal system
WS Pediatrics
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:3207
Deposited By: MS Soghra Golmaghani
Deposited On:17 Dec 1390 11:56
Last Modified:13 Dec 1391 11:57

Repository Staff Only: item control page

Document Downloads

More statistics for this item...