داپسون به عنوان یک درمان جایگزین در کودکان مبتلا به تب مدیترانه ای فامیلی

صالح زاده, فرهاد ، جهانگیری, سپیده ، محمدی کلاسرلو, ایلنار (1390) داپسون به عنوان یک درمان جایگزین در کودکان مبتلا به تب مدیترانه ای فامیلی. Iranian Journal of Pediatrics ــ 22 (1). ص.ص.23-27. شاپا 2008-2142

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آدرس اینترنتی رسمی : http://ijp.tums.ac.ir/index.php/ijp/article/view/1...

عنوان انگليسي


خلاصه انگلیسی

Objective: Familial Mediterranan Fever is an hereditary autoinflammatory disease that presents with recurrent febrile attacks and poly serositis. Colchicine is the only known treatment in this diease. However, nearly 5-10% of patients are resistant to colchicines. There are many different modalities in colchicine resistant patients, biologic and immunosupressive drugs being the known ones. We studied the efficacy of Dapsone as an anti inflammatory drug in children with FMF who did not tolerate colchicine well. Methods: This is a case series study in 10 patients who had FMF on the base of Tel-Hashomer criteria and did not tolerate colchicine or did not respond to it well. Patients took 2mg/kg dapsone in single dose, during 6 months. Findings In four patients episodic attacks returned after 27 days, so the drug was discontinued. One patient refused to continue the study; in five patients dapsone was taken in average for 8 months and 6 days, at least for 6 months. These five patients had no episodes of attack during the following observation. Conclusion: Dapsone could control episodic attacks of FMF in 50% of cases. It might be considered as an alternative therapy in FMF cases not responding to colchicine.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :فرهاد صالح زاده
اطلاعات اضافی :Impact Factor 2010: 0.148 Indexed in:1-ISI (Citation Index Expanded) 2-Embase, Scopus 3- CINAHL , Bioline International website,Global Health Directory Open Access Journals (DOAJ), Eastern Mediterranean Index Medicus (IMMER) ,National Library for Health , Sientific Information System (SID) Iranmedex ,Magiran , EMRMedex , Genamics-JournalSeek Index Copernicus , MedBioWorld , Nutrition and Food Sciences Open J-Gate , Ulrich database ,Electronic Journals Index (SJSU) , Electronic Journals Library (EZB)
کلیدواژه ها (انگلیسی):Dapsone; Familial Mediterranan Fever; Periodic Fever; Children
موضوعات :WB پزشکی عملی
WE سیستم عضلانی اسکلتی
WS بیماریهای کودکان
بخش های دانشگاهی :دانشكده پزشكي > گروه اطفال ، پزشکی اجتماعی
کد شناسایی :3207
ارائه شده توسط : خانم صغری گلمغانی
ارائه شده در تاریخ :17 اسفند 1390 11:56
آخرین تغییر :13 اسفند 1391 11:57

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