ارزیابی تاثیر Preconditioning مرحله ای بر فاکتورهای بیوشیمیایی در بیماران تحت عمل جراحی CABG

محمدزاده, علیرضا and جعفری, ناصر and باباپور, بهزاد and دوستکامی, حسین and حسینیان, عدالت and حسن پور, محمد (1391) ارزیابی تاثیر Preconditioning مرحله ای بر فاکتورهای بیوشیمیایی در بیماران تحت عمل جراحی CABG. ISRN Cardiology ــ 2012 (2012). pp. 4-1. شاپا 2090-5599

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Official URL: http://www.isrn.com/journals/cardiology/


Effect of Staged Preconditioning on BiochemicalMarkers in the Patients Undergoing Coronary Artery Bypass Grafting

English Abstract

The present study has investigated the effectiveness of staged-preconditioning, in both remote and target organs. After IP the myocardial release of the biochemicalmarkers including, creatine phosphokinase (CPK), cardiac creatine kinase (CK-MB), cardiac troponin T (cTnT) and lactate dehydrogenase (LDH) were evaluated in patients who underwent CABG, with and without staged-preconditioning. Sixty-one patients entered the study; there were 32 patients in the staged-preconditioning group and 29 patients in the control group. All patients underwent on-pump CABG using cardiopulmonary bypass (CPB) techniques. In the staged-preconditioning group, patients underwent two stages of IP on remote (upper limb) and target organs. Each stage of preconditioning was carried out by 3 cycles of ischemia and then reperfusion. Serum levels of biochemical markers were immediately measured postoperatively at 24, 48 and 72 h. Serum CK-MB, CPK and LDH levels were significantly lower in the staged-preconditioning group than in the control group. The CK-MB release in the staged-preconditioning patients reduced by 51% in comparison with controls over 72 h after CABG. These results suggest that myocardial injury was attenuated by the effect of three rounds of both remote and target organ IP.

Item Type:Article
زبان سند : انگلیسی
مجری اصلی :علیرضا محمدزاده
نویسنده مسئول :ناصر جعفری
همکار طرح :بهزاد باباپور
همکار طرح :حسین دوستکامی
همکار طرح :عدالت حسینیان
همکار طرح :محمد حسن پور
Additional Information:Indexed in: PubMed/PMC , google Scholar, DOAJ
کلیدواژه ها (انگلیسی):Staged Preconditioning, Biochemical Markers, Coronary artery bypass grafting
Subjects:QU Biochemistry
WG Cardiovascular System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:3479
Deposited By: Mr Naser Jafari
Deposited On:07 Jun 1391 11:15
Last Modified:11 Apr 1399 12:22

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