تقی پور, زهرا and کربلایی, خدیجه and کیانی, عباس and نیاپور, علی and بهرامیان, حمید and نصر اصفهاني, محمد حسين and بهاروند, حسين (1390) سلولهای بنیادی استخراج شده از پالپ دندان شیری بصورت تمایز نیافته و القا شده سبب بهبودی حرکتی دررت های ضایعه نخاعی از نوع کوفتگی می گردد. Stem Cells and Development ــ 21 (10). pp. 1794-1803. شاپا 1547-3287
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Official URL: http://www.liebertonline.com/doi/abs/10.1089/scd.2...
Title
Transplantation of Undifferentiated and Induced Human Exfoliated Deciduous Teeth-derived Stem Cells Promote Functional Recovery of Rat Spinal Cord Contusion Injury Model.
English Abstract
Regarding both the neural crest origin and neuronal potential of stem cells from human exfoliated deciduous teeth (SHED), here, we assessed their potential in addition to neural induced SHED (iSHED) for functional recovery when transplanted in a rat model for acute contused spinal cord injury (SCI). Following transplantation, a significant functional recovery was observed in both groups relative to the vehicle and control groups as determined by the BBB functional test. We also observed that animals who received iSHED were in a better state in contrast to the SHED group. Immunohistofluorescence evaluation five weeks after transplantation showed neuronal and glial differentiation and limited proliferation in both groups. However, MBP and NG2, oligodendrocyte markers were increased and GFAP, astrocyte marker was decreased in the iSHED group in comparison with the SHED group. These findings have demonstrated that transplantation of SHED or its derivatives could be a suitable candidate for the treatment of SCI as well as other neuronal degenerative diseases.
| Item Type: | Article |
|---|---|
| زبان سند : | انگلیسی |
| نویسنده اول : | زهرا تقی پور |
| نویسنده مسئول : | محمد حسين نصر اصفهاني |
| نویسنده مسئول : | حسين بهاروند |
| Additional Information: | Impact Factor 2010 is 4.791 Idexed: 1-Science Citation Index Expanded; Science Citation Index; 2-MEDLINE; 3-Current Contents/Life Sciences; Current Contents/Clinical Medicine; Biotechnology Citation Index; Journal Citation Reports/Science Edition; EMBASE/Excerpta Medica; EMBiology; Scopus |
| کلیدواژه ها (انگلیسی): | Neural Induction; Stem Cells from Human Exfoliated Deciduous Teeth (SHED); Spinal Cord Injury; Transplantation. |
| Subjects: | QS Human Anatomy WL Nervous system |
| Divisions: | Faculty of Medicine > Department of Basic Sciences > Department of Anatomy |
| ID Code: | 3529 |
| Deposited By: | Dr Ali Niapour |
| Deposited On: | 03 Jul 1391 12:09 |
| Last Modified: | 04 Nov 1391 08:45 |
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- سلولهای بنیادی استخراج شده از پالپ دندان شیری بصورت تمایز نیافته و القا شده سبب بهبودی حرکتی دررت های ضایعه نخاعی از نوع کوفتگی می گردد. (deposited 03 Jul 1391 12:09) [Currently Displayed]
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