title

تالیدوماید با مهار سایتوکاین های پیش التهابی، دیابت ناشی از استرپتوزوتوسین را در مدل موش آزمایشگاهی کاهش می دهد

امیرشاهرخی, کیوان and قاضی خوانساری, محمود (1391) تالیدوماید با مهار سایتوکاین های پیش التهابی، دیابت ناشی از استرپتوزوتوسین را در مدل موش آزمایشگاهی کاهش می دهد. Cytokine ــ 60 (2). pp. 522-527. شاپا 1043-4666

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Official URL: http://www.sciencedirect.com/science/journal/10434...


Title

Thalidomide attenuates multiple low-dose streptozotocin-induced diabetes in mice by inhibition of proinflammatory cytokines

English Abstract

Thalidomide is an immunomodulatory and anti-inflammatory agent and is used in autoimmune disorders. It has been shown that thalidomide inhibits proinflammatory cytokines production. The purpose of this study was to investigate the effect of thalidomide on the prevention of autoimmune diabetes in mice. Diabetes was induced by multiple low-dose of streptozotocin (MLDS) injection. Mice were treated with thalidomide (300mg/kg/day orally) for 21 days. Plasma levels of glucose, insulin and nitrate/nitrite as well as pancreatic cytokine levels were measured. Pathological examinations of the pancreas revealed that thalidomide reduced the islet inflammation (insulitis) and destruction of beta cells. Thalidomide treatment prevented hyperglycemia and preserved pancreatic insulin secretion in the diabetic mice. Thalidomide treatment also significantly decreased plasma levels of nitric oxide and pancreatic proinflammatory cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-12, IL-17 and interferon (IFN)-γ)] while increased anti-inflammatory cytokine IL-10. In conclusion, these findings indicate that thalidomide may have a protective effect against the autoimmune destruction of the pancreatic beta-cells during the development of MLDS-induced type 1 diabetes in mice.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :محمود قاضی خوانساری
Additional Information:Impact Factor : 3.019 Abstracting and Indexing: 1- Science Citation Index,Science Citation Index Expanded,ISI ,2-MEDLINE ,3- BIOSIS , Chemical Abstracts , Current Contents , EMBASE , Scopus
کلیدواژه ها (انگلیسی):Thalidomide, Type 1 diabetes, Cytokines, Nitric oxide
Subjects:QV pharmacology
WK Endocrine System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:3567
Deposited By: Dr Kivan Amir Shahrikhi
Deposited On:04 Aug 1391 10:56
Last Modified:07 Jul 1393 06:08

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