تاثیر مکمل اسیدهای چرب امگا سه بر وضعیت تغذیه بیماران مبتلا به سرطان معده تحت شیمی درمانی

Title

Effect of omega-3 fatty acid supplementation on nutritional status in patients with gastric cancer during chemotherapy

English Abstract

Background: Although some studies have shown positive effects of omega-3 fattyacid supplementation on nutritional status of cancer patients undergoing differenttreatments, there is no consistency in results. The aim of this study was to examinethe effects of omega-3 fatty acid on the nutritional status of gastric cancer patientsduring the course of chemotherapy. Methods: In a double-blind clinical trial, 30 adult patients with gastric cancerreceiving chemotherapy were randomized into a supplement and a placebo groupsand given daily, for 6 weeks, a 3-g omega-3 fatty acid supplement (containing 1.8geicosapentaeonic plus 1.2g docosahexaenoic acid) and oral paraffin, respectively.Anthropometric data was collected and nutritional status assessed at the beginning,at week 4 and at the end of week 6. The data were analyzed using repeatedmeasures ANOVA and independent sample t-test. Results: The findings indicated that omega-3 fatty acid supplementation increasedbody weight, mean daily intake of energy and macronutrients, serum levels oftransferrin and albumin at the end of the 6-week period significantly (p<0.05). Allthese variables decreased in the placebo group (p<0.05). The increases in bodyweight, energy and carbohydrate intakes, and serum levels of albumin in thesupplement group were time-dependent (p<0.05). Conclusion: The results of present study showed that omega-3 fatty acidsupplementation can improve nutritional status in patients with gastric cancerduring the course of chemotherapy. We recommend using omega-3 fatty acidsupplement in patients with gastric cancer during chemotherapy.

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