اثر حفاظتی متیل سولفونیل متان بر همودنیامیک و استرس اکسیداتیو در پر فشاری خون ریوی ناشی از تجویز مونوکروتالین در موش بزرگ آزمایشگاهی

محمدی, پرهام سعداله and نجفی, مسلم and همزه ای, حسین and مالکی نژاد, نسرین and پزشکیان, مسعود and صادقی, همایون and دارابی, مسعود and مصطفی لو, سارا and بهلولی, شهاب and گرجانی, علیرضا (1391) اثر حفاظتی متیل سولفونیل متان بر همودنیامیک و استرس اکسیداتیو در پر فشاری خون ریوی ناشی از تجویز مونوکروتالین در موش بزرگ آزمایشگاهی. Advances in Pharmacological Sciences ــ 2012 (507278). pp. 1-6. شاپا 1687-6342

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Protective effects of methylsulfonylmethane on hemodynamics and oxidative stress in monocrotaline-induced pulmonary hypertensive rats

English Abstract

Methylsulfonylmethane (MSM) is naturally occurring organic sulfur that is known as a potent antioxidant/anti-inflammatory compound. The aim of this study was to investigate the effect of MSM on hemodynamics functions and oxidative stress in rats with monocrotaline- (MCT-) induced pulmonary arterial hypertension (PAH). Wistar rats were randomly assigned to 38-days treatment. MSM was administered to rats at 100, 200, and 400 mg/kg/day doses 10 days before a single dose of 60 mg/kg, IP, MCT. Hemodynamics of ventricles were determined by Powerlab AD instrument. Blood samples were obtained to evaluate changes in the antioxidative system including activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and the level of reduced glutathione (GSH) and malondialdehyde (MDA). Improvements in cardiopulmonary hemodynamics were observed in the MSM-treated pulmonary arterial hypertensive rats, with a significant reduction in right ventricular systolic pressure (RSVP) and an increase in the mean arterial pressure (MAP). The values of CAT, SOD, GSH-px activities, and GSH were significantly lower in MCT-induced PAH (P < 0.01), but they were recovered to control levels of MSM-treated groups. Our present results suggest that long-term administration of the MSM attenuates MCT-induced PAH in rats through modulation of oxidative stress and antioxidant defense. © 2012 Sadollah Mohammadi et al.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :پرهام سعداله محمدی
نویسنده :سارا مصطفی لو
نویسنده :شهاب بهلولی
نویسنده مسئول :علیرضا گرجانی
Additional Information:indexed in : Chemical Abstracts, CSA , DOAJ), EMBASE, Google Scholar, PubMed Central, Scopus
کلیدواژه ها (انگلیسی):catalase; dimethyl sulfone; glutathione; glutathione peroxidase; malonaldehyde; monocrotaline; superoxide dismutase, animal experiment; animal model; animal tissue; antioxidant activity; article; body weight; cardiopulmonary hemodynamics; chronic drug administration; controlled study; dose response; enzyme activity; heart rate; heart ventricle; heart ventricle contraction; heart weight; lipid peroxidation; lung weight; male; mean arterial pressure; nonhuman; oxidative stress; priority journal; pulmonary hypertension; rat; single drug dose
Subjects:QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:3867
Deposited By: Dr Shahab Bohlooli
Deposited On:26 Oct 1391 16:32
Last Modified:21 Feb 1399 21:41

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