كاهش ضايعه ايسكميك موضعي مغز به دنبال مهار بعد ايسكمي آنزيم تبديل كننده آنژيوتانسين در موش صحرائي با فشار خون طبيعي.

پناهپور, حمداله and دهقان, غلامعباس (1391) كاهش ضايعه ايسكميك موضعي مغز به دنبال مهار بعد ايسكمي آنزيم تبديل كننده آنژيوتانسين در موش صحرائي با فشار خون طبيعي. Iranian Biomedical Journal ــ 16 (4). pp. 202-208. شاپا 1028-852X

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Official URL: http://ibj.pasteur.ac.ir/browse.php?a_id=762&sid=1...


Attenuation of Focal Cerebral Ischemic Injury Following Post Ischemic Inhibition of Angiotensin Converting Enzyme (ACE) Activity in Normotensive Rat

English Abstract

Central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. Our previous work showed that inhibition of angiotensin converting enzyme (ACE) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (I/R) injuries. This study evaluated the impacts of post-ischemic inhibition of ACE, enalapril, on brain infarction in normotensive rats. Methods: Rats were anesthetized with chloral hydrate (400 mg/kg). Focal cerebral ischemia was induced by 60-min intraluminal occlusion of right middle cerebral artery (MCA). Intraperitoneal injection of enalapril (0.03 or 0.1 mg/kg) was done after MCA reopening (reperfusion). Neurological deficit score (NDS) was evaluated after 24 h and the animals randomly assigned for the assessments of infarction, absolute brain water content (ABWC) and index of brain edema. Results: Severe impaired motor functions (NDS = 2.78 ± 0.28), massive infarction (cortex = 214 ± 19 mm3, striatum = 86 ± 5 mm3) and edema (ABWC = 83.1 ± 0.46%) were observed in non-treated ischemic rats. Nonhypotensive dose of enalapril (0.03 mg/kg) significantly reduced NDS (1.5 ± 0.22), infarction (cortex = 102 ± 16 mm3, striatum = 38 ± 5 mm3) and edema (ABWC = 80.9 ± 0.81%). Enalapril at dose of 0.1 mg/kg significantly lowered arterial pressure could not improve NDS (2.0 ± 0.45) and reduce infarction (cortex = 166 ± 26 mm3, striatum = 71 ± 11 mm3). Conclusion: Post-ischemic ACE inhibition in the normotensive rats without affecting arterial pressure protects the brain from reperfusion injuries; however, this beneficial action is masked by hypotension.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حمداله پناهپور
نویسنده مسئول :غلامعباس دهقان
Additional Information: IBJ is indexing in: PubMed/MEDLINE, Index Medicus, CINAHL, BIOBASE, Scopus, Google Scholar, Chemical Abstracts, Index Copernicus, CAB Abstracts, Cambridge Scientific Abstracts, CINAHL Plus, EMBASE/Excerpta Medica, VCU Library, Directory of Open Access Journals (DOAJ), Index Medicus for the WHO Eastern Mediteranean Region (IMEMR), Islamic World ience Islamic World Science Citation Database (ISC)
کلیدواژه ها (انگلیسی):Angiotensin converting enzyme (ACE) inhibitors, Enalapril, Brain edema, Cerebral infarction
Subjects:QT physiology
QV pharmacology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:4064
Deposited By: Dr Hamdollah Panahpour
Deposited On:22 Dec 1391 13:06
Last Modified:22 Dec 1391 13:06

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