تأثیر مکمل یاری روی بر وضعیت آنتی اکسیدانی و پراکسیداسیون لیپیدی در بیماران همودیالیزی

مأذنی, محمد and ارگانی, حسن and رشتچي زاده, نادره and قربانی حق جو, امیر and حمیدی, امیر and اصغری استیار, مهرداد and نظامی, نریمان (1392) تأثیر مکمل یاری روی بر وضعیت آنتی اکسیدانی و پراکسیداسیون لیپیدی در بیماران همودیالیزی. Journal of Renal Nutition ــ 23 (3). pp. 180-184. شاپا 1051-2276

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Effects of Zinc Supplementation on Antioxidant Status and Lipid Peroxidation in Hemodialysis Patients

English Abstract

OBJECTIVES: This study was designed to determine the effects of zinc supplementation on oxidative stress in hemodialysis (HD) patients through evaluating total antioxidant capacity (TAC), whole blood glutathione peroxidase (GSH) level, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) level. DESIGN AND SETTING: Double-blinded randomized controlled trialfrom October 2006 to December 2007 at Tabriz Imam Khomeini Hospital. SUBJECTS: Sixty-five HD patients were randomly enrolled into 2 groups. INTERVENTION: Patients received placebo in group A and zinc (100 mg/day) in group B for 2 months. After a washout period for 2 months, the groups were crossed over and the study was continued for an additional 2 months. MAIN OUTCOME MEASURES: Serum zinc concentration was measured using atomic absorption spectrophotometry. TAC, GSH level, and SOD activity were determined by commercial enzyme-linked immunosorbent assay kits. MDA level was measured using a thiobarbituric acid method. RESULTS: The levels of serum zinc, TAC, GSH (P < .001 for all), and SOD activity (P < .001 for group A and P = .003 for group B) significantly increased after zinc supplementation whereas the serum level of MDA decreased after the same period (P = .003 for group A and P < .001 for group B). CONCLUSIONS: Zinc supplementation for 2 months improved the serum levels of zinc, antioxidant status, and lipid peroxidation in HD patients.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد مأذنی
نویسنده مسئول :نریمان نظامی
Additional Information:Impact Factor: 1.570 Indexing in : Science Citation Index Expanded , Current Contents - Clinical Medicine , PubMed /Medline , Scopus , Index medicus , Google scholar ,
Uncontrolled Keywords:روی ، همودیالیز ، پراکسیداسیون لیپیدی
کلیدواژه ها (انگلیسی):Zinc , Hemodialysis , Lipid Peroxidation
Subjects:QU Biochemistry
WJ Urogenital System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:4075
Deposited By: Dr Mohammad Mazani
Deposited On:01 Mar 1392 08:06
Last Modified:07 Oct 1392 11:21

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