نقش پیشگویی کننده پپسینوژن یک و دو در تشخیص گاستریت آتروفیک در مناطقی با بروز متفاوت از کانسر معده

محمدخانی, اشرف and درویش مقدم, صدیف and سلمانرخانی, حسن and علاف اصغری, امین and یزدانبد, عباس and میرزایی, محبوبه and حاج شیخ الاسلامی, ارغوان and بشیری, جعفر and سجادی, علیرضا and مسرت, صادق (1392) نقش پیشگویی کننده پپسینوژن یک و دو در تشخیص گاستریت آتروفیک در مناطقی با بروز متفاوت از کانسر معده. Archives of Iranian Medicine ــ 16 (4). pp. 208-212. شاپا 1029-2977

Text - Published Version

Official URL: http://www.aimjournal.ir/article.aspx?id=464


Are the Serum Biomarkers Pepsinogen I and II Good Predictors for the Detection of Subjects with Atrophic Gastritis in Areas that have Different Gastric Cancer Incidence.

English Abstract

BACKGROUND: Northern Iran (Ardabil) is characterized by a high gastric cancer (GC) rate, whereas Southern Iran (Kerman and Yazd) has a low GC rate. The aim of this study is to verify the potential for pepsinogen I and II to detect atrophic gastritis (AG) in both high and low risk populations for GC. METHODS: Sera of blood donors and patients with GC from Ardebil, Kerman and Yazd were used to measure levels of pepsinogen I, II and H. pylori IgG antibody. GC rates in these cities were determined according to the Cancer Registry and upper gastrointestinal (GI) endoscopy results. RESULTS: There were 449 subjects with an average age of 45 ± 15 years. The GC rate in the endoscopy units of the hospital in Ardabil was four times higher than Kerman or Yazd. The mean serum pepsinogen I levels did not differ between Ardabil (102 ± 42.6 µg/mL), Kerman (103.3 ± 49.8 µg/mL), and Yazd (111.7 ± 39 µg/mL). Pepsinogen II levels were: 8.1 ± 4.7 µg/mL (Ardabil), 7.5 ± 5.3 µg/mL (Kerman), and 7.6 ± 4.4 µg/mL (Yazd), which were not different. The H. pylori infection rates were: Ardabil (61%), Kerman (55%), and Yazd (73%). A low ratio of pepsinogen I to II (≤3) was seen in Ardabil (1.3%), Kerman (1.9%), and Yazd (0.0%), which was not significant. A total of 51.9% of GC patients from Ardabil had normal pepsinogen I (≥70 µg/mL) levels and pepsinogen I/II ratios that were >5. CONCLUSION: Serum biomarkers pepsinogen I and II and their ratios are probably not sensitive predictors of AG in areas that have either a high or low GC prevalence. This finding is likely related to the lack of an association between GC and advanced AG.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :اشرف محمدخانی
نویسنده :عباس یزدانبد
نویسنده مسئول :صادق مسرت
Additional Information:Impact Factor: 0.972 Indexed in PubMed/MEDLINE, ISI Web of Science, EMBASE, SCOPUS, CINHAL, PASCAL, CSA, SID
کلیدواژه ها (انگلیسی):Biomarker, Gastric cancer, Pepsinogen I, Pepsinogen II
Subjects:QU Biochemistry
WI Digestive System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:4164
Deposited By: Dr Shahram Habibzadeh
Deposited On:17 Feb 1392 09:24
Last Modified:07 Jul 1393 06:44

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