ارتباط میان ژنوتیپ های هاپتوگلوبین و وضعیت التهابی با سطح هموگلوبین در بیماران واجد کم خونی مبتلا به بیماری کلیوی مزمن مرحله ۴

Title

Haptoglobin genotypes, inflammation status and their associations with hemoglobin levels in stage 4 chronic kidney disease patients with anemia

English Abstract

Background and aims: Anemia and increased inflammation are the main causes of mortality in chronic kidney disease (CKD) patients. This study was designed to explore the probable relationship of hemoglobin (Hb) with serum haptoglobin (HP), its genotypes and inflammation statues in CKD stage 4 patients with anemia. Methods: The subjects of the study was 40 anemic CKD patients on stage 4 [GFR = 15 - 29 ml/ min/1.73 m2]. Serum biochemical factors as well as ferritin, HP and IL-6 levels were measured by standard methods. Haptoglobin genotypes were determent by PCR method and the accuracy of genotyping was confirmed by sequencing amplified fragments and RFLP analysis. Results: Results showed that although HP2-2 was the most common genotype (%72.5), no significant correlations between HP genotypes with Hb and HP levels were found (p= 0.49, p= 0.32, respectively). Significant negative correlation between Hb level with IL-6 and hs-CRP levels (p< 0.001 and p< 0.05, respectively) and a significant positive correlation between Hb and ferritin levels was found (p< 0.05). Conclusion: The results suggest that HP genotype and serum HP levels have no significant effect on hemoglobin level in CKD stage 4 patients. However, Hb level is associated with inflammation and albumin status.

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