پیرایش متغیر ژن BRCA1 در سرطان پستان

وثوقی, ابراهیم and فغانی, نفیسه and مهدی پور, پروین and اخوان, هما and اصغراوا, طاهیرا and پیری دوگاهه, هادی and حسینی اصل, سید سعید (1392) پیرایش متغیر ژن BRCA1 در سرطان پستان. Annals of Biological Research ــ 4 (4). pp. 139-143. شاپا 0976-1233

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BRCA1 alternative splicing in breast tumorogenesis

English Abstract

Introduction: Alternative splicing helps transcription process to produce many proteins from single gene and has important roles on tumorogenesis. The BRCA1 gene has almost 11 alternate spliced variants which have been mentioned as susceptibility factors for initiation and progression of breast cancer. Materials and Methods: The expression of BRCA1 was analyzed by qualitative and quantitative RT-PCR assays, among 27 samples from patients with primary breast cancer. Then the variants Δ2, Δ11b, and Δ14 were detected. Results: The BRCA1 gene found to be expressed among 85.2% of tumors. The distribution of Δ2, Δ11b, and Δ14 variants were 91.3%, 73.9%, and 78.3%, respectively. Discussion: The findings about three investigated variants emphasize on importance of BRCA1 alternative splicing for breast tumorogenesis.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :ابراهیم وثوقی
نویسنده :نفیسه فغانی
نویسنده :پروین مهدی پور
نویسنده :هما اخوان
نویسنده :طاهیرا اصغراوا
نویسنده :هادی پیری دوگاهه
نویسنده مسئول :سید سعید حسینی اصل
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کلیدواژه ها (انگلیسی):BRCA1 , Breast cancer , alternative splicing
Subjects:QY Clinical Pathology
WP Gynecology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:4191
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:25 Feb 1392 07:47
Last Modified:06 Jun 1397 08:51

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