خطر خانوادگی سرطان معده در بیماران بقا یافته از سرطان پستان اولیه

Title

The familial risk of gastric cancer on the survival of patients with primary breast cancer

English Abstract

Objective:The different germline mutations are known to cause breast cancer (BC), which might have induced as some other malignancies in degrees of relatives, and an increased risk of developing BC and clinical outcomes. Therefore we aim to investigate whether the independent familial gastric cancer (FGC) influence the survival of Iranian breast cancer patients. Methods:Totally BC phenotype in 736 pedigrees ascertained through BC probands with primary breast cancer. Information on FH for BC was obtained at diagnosis by interview. Hazard ratios (HRs) and the corresponding 95% confidence intervals (95% CIs), adjusted for confounding factors, were computed using proportional hazard models. Results:Gastric cancer was found the most frequent carcinoma after BC across pedigrees (13%). The probands of BC with positive FH of BC show longer survival, compared with no-FH patients (86 vs. 69 months; Log rank test, Chi-square= 3.8, P=0.093). The survival of probands who had 1st, 2nd, 3rd or 2nd /3rd degree of relatives included 69, 86, 90 or 63 months, respectively (log rank test, Chi-square=3.11, P=0.048). When BC accompanied with GC in relatives, probands with 2nd and 3rd degrees show 60 and 91 months survival, respectively (log rank test, Chi-square=3.34, P=0.083). When adjustment for age, site, tumor size, ER, metastasis and treatments performed hazard ratio (HR) for poorer survival in FH positive of GC was 0.612(95%CI: 0.057-0.997). Therefore, corresponding results show that FH of gastric carcinoma may predict the risk of survival inversely, but the closure affected degree of relatives likely provide poorer prognosis for BC patients' survival thorough pedigrees aggregation.

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