![]() Back to
Conference page |
UICC World Cancer Congress 2006Bridging the Gap: Transforming Knowledge into ActionJuly 8-12, 2006, Washington, DC, USA |
Methods:Totally BC phenotype in 736 pedigrees ascertained through Iranian BC probands with primary breast cancer, 1994-2005. Information on FH for BC was obtained at diagnosis by interview. The independent pathologic features and age at diagnosis verified across FH status. Some potential confounding factors were adjusted for analysis of odds ratios (OR).
Results:The median age of patients was 47 year. The observed frequency of metastase were significantly high in cases younger than 45 year (F=5.746, P=0.045). Among patients with no FH the risk of developing the metastases were high in younger cases, 15-39 y (OR=1.55, 95%CI: 0.299-8.082). The similar trend for risk was obvious for BC patients in which lower ORs non-significantly obtained (15-39 y: OR=1.42, 95%CI: 0.099-21.562). The involved left site of BC predicted lower risk for metastasis development (OR=0.681; 95% CI: 0.501-0.922). In FH positive patients the left sites associated positively with metastasis (OR= 1.541; 95% CI: 0.865-2.744). The same contribution was obtained for unilaterality (OR= 2.108; 95% CI: 0.597-7.452). In the cases of positive FH the tumor size predicted undesired outcomes with considerable risk (OR: 1.5-1.23).Therefore, The FH inversely associated with the developing of metastasis, whilst it is controlled, age of onset, site, tumor size and laterality predispose metastasis as undesired clinicopathological outcome and might be consider for preventive and therapeutic respects.
See more of Cancer Research,
Detection and Treatment
See more of Cancer
Research, Detection and Treatment
See more of The
UICC World Cancer Congress 2006