ارتباط معنی دار میان چند ریختی MTHFR C677T و سرطان معده در استان اردبیل

حسینی اصل, سید سعید and یزدانبد, عباس and فرهمند بیگی, نیما and پورفرضی, فرهاد and اخوان, هما and مأذنی, محمد (1390) ارتباط معنی دار میان چند ریختی MTHFR C677T و سرطان معده در استان اردبیل. در: ESMO 13th World Congress on Gastrointestinal Cancer , 22-25 June, 2011, Barcelona, Spain .

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Official URL: http://worldgicancer.com/wcgi/wgic2011/index.html



English Abstract

Background: Gastric Cancer (GC) as the third most common malignancy in Iran, accounts for �50% of all GI cancers who cause 55% of all cancer-related deaths in Iran. The rates of GC reported from Ardabil Province are among the highest in the world. Upper gastrointestinal cancer accounts for more than 50% of all cancer deaths in this area. Methylenetetrahydrofolate reductase (MTHFR) enzyme reductase catalyzes the conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, and some types of cancer, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. Individual with two copies of 677C (677CC) have the "normal" or "wildtype" genotype. Individuals of 677TT are predisposed to mild hyperhomocysteinemia, because they have less active MTHFR available to produce 5-methyltetrahydrofolate (which is used to decrease homocysteine). We aimed to study the association between this polymorphism and GC in our province. Methods: We enrolled 100 patients with mean age 65.9 Yrs. affected with primary GC and same age- and sex- matched healthy control participants. The analysis has been carried out by PCR-RFLP on DNA extractions from peripheral blood. Results: In the case group, the genotype was 45%, 515%, and 4% for CC, CT, and TT, respectively. And for controls were 62%, 33%, and 5%. In comparing case and control group, a significant association was found (P=0.006). Conclusion: Because of high frequency of GC in our province, the investigations about the role of genetic susceptibilities for GC are very important. Finding relationships could help us to find prognostic factors for persons who are at the risk of affecting to GC in.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :سید سعید حسینی اصل
نویسنده :عباس یزدانبد
نویسنده :نیما فرهمند بیگی
نویسنده :فرهاد پورفرضی
نویسنده :هما اخوان
نویسنده :محمد مأذنی
کلیدواژه ها (انگلیسی):POLYMORPHISM , Cancer , MTHFR C677T
Subjects:QY Clinical Pathology
WI Digestive System
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:4239
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:18 Mar 1392 08:29
Last Modified:20 Mar 1392 07:43

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