عدم ارتباط میان چند ریختی حذف ـاضافه در ژن ACE و سرطان معده در استان اردبیل

نیک منش, مهرداد and حسینی اصل, سید سعید and یزدانبد, عباس and پورفرضی, فرهاد and دیده ور, رضا and اخوان, هما (1390) عدم ارتباط میان چند ریختی حذف ـاضافه در ژن ACE و سرطان معده در استان اردبیل. در: ESMO 13th World Congress on Gastrointestinal Cancer , 22-25 June, 2011, Barcelona, Spain .

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Official URL: http://worldgicancer.com/wcgi/wgic2011/index.html



English Abstract

Background: Gastric cancer as the 3rd most common malignancy in Iran, accounts for �50% of all GI cancers who cause 55% of all cancer-related deaths in Iran. The rates of gastric cancer reported from Ardabil province, Iran, are among the highest in the world. Upper gastrointestinal cancer accounts for more than 50% of all cancer deaths in this area. The angiotensin-converting enzyme (ACE) plays an important role not only in the regulation of vascular homeostasis but also in stimulation of hematopoiesis. The insertion/deletion polymorphism of ACE gene has recently been linked to the pathogenesis and progression of human cancers. We aimed to evaluate the association between insertion/deletion (I/D) polymorphism of the ACE gene and susceptibility to gastric cancer in our province. Methods: We enrolled 97 patients with gastric cancer and 97 age- and sex-matched healthy control participants. This length polymorphism was revealed by conventional PCR method on DNA extracted from peripheral blood. Results: Among cases, there were 18.6% homozygous for II, 26.8% homozygous for DD, and the remaining 54.6% were ID. The resulted Controls data were 19.2% homozygous for II, 46.5% homozygous for DD, and 34.3% for ID. Any significant correlations were not found between cases and controls (p=0.47) or pathologic values in case group. Conclusion: Finding any correlation in this investigation could results from the reported relationships between the noted polymorphism and some disorders such as Diabetes which were undetected in some of our participants. But, theoretically this length polymorphism seems to offer the susceptibility to Gastric cancer.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :مهرداد نیک منش
نویسنده :سید سعید حسینی اصل
نویسنده :عباس یزدانبد
نویسنده :فرهاد پورفرضی
نویسنده :رضا دیده ور
نویسنده :هما اخوان
کلیدواژه ها (انگلیسی):GASTRIC CANCER , Iran , Ardabil , POLYMORPHISM
Subjects:QZ Pathology
WI Digestive System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:4240
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:18 Mar 1392 08:41
Last Modified:31 Apr 1392 11:05

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