ارتباط میان چند ریختی ARG72PRO در ژن TP53 و سرطان معده در استان اردبیل

اخوان, هما and برزگر, ابوذر and نیک منش, مهرداد and یزدانبد, عباس and مأذنی, محمد and پورفرضی, فرهاد and دیده ور, رضا and نوبخت, حسین and بشیری, جعفر and ملک زاده, رضا and حسینی اصل, سید سعید (1388) ارتباط میان چند ریختی ARG72PRO در ژن TP53 و سرطان معده در استان اردبیل. در: 21st European students conference, 13-17th October, 2010, Berlin, Germany.

Text - Published Version


Association between TP53 gene ARG72PRO polymorphism and gastric cancer in Ardabil Province,Iran.

English Abstract

Int roduct ion: Gastric cancer (GC) as the 3rd most common malignancy in Iran, accounts for ~50% of all GI cancers who cause 55% of all cancer-related deaths in Iran. The rates of GC reported from Ardabil province, Iran, are among the highest in the world. Upper gastrointestinal cancer accounts for more than 50% of all cancer deaths in this area. Codon 72 polymorphism of the tumor suppressor gene TP53 has been associated with a higher risk in the development of several types of cancer. The polymorphism results in a variant protein with either an arginine (CGC) or a proline residue (CCC). We aimed analyze the association of the TP53 codon 72 polymorphism with the risk of developing gastric cancer in a high-risk population around the world. Material s and Methods : We enrolled 87 patients with mean age 65.9 (range: 37-87; std.=11.1) affected with primary gastric cancer (GC) and same age- and sex-matched healthy control participants. The analysis has been done by PCR-RFLP on DNA extractions from peripheral blood. Resul t s : In case group the genotype was 16.1%, 42.5%, and 41.4% for Arg/Arg, Arg/Pro, and Pro/Pro, respectively. And for controls those were 18.5%, 40.2%, and 41.4%. In comparing case and control group, no significant correlation was found (p=0.9). Also, there was any significant correlation between codon 72 status and pathologic data. Conclus ion: Because of the high frequency of GC in our province, the investigations about the role of genetic susceptibilities for GC are very important. In spite of finding no relationship between P53 polymorphisms, studying other genetic variations is recommended.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده اول :هما اخوان
نویسنده :ابوذر برزگر
نویسنده :مهرداد نیک منش
نویسنده :عباس یزدانبد
نویسنده :محمد مأذنی
نویسنده :فرهاد پورفرضی
نویسنده :رضا دیده ور
نویسنده :حسین نوبخت
نویسنده :جعفر بشیری
نویسنده :رضا ملک زاده
نویسنده مسئول :سید سعید حسینی اصل
کلیدواژه ها (انگلیسی):Gastric cancer , polymorphism , TP53 , gene
Subjects:QZ Pathology
WI Digestive System
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:4241
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:27 Mar 1392 08:36
Last Modified:21 May 1392 11:45

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