اپی ژنتیک

حسینی اصل, سید سعید (1392) اپی ژنتیک. [Teaching Resource]

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English Abstract

DNA Methylation •DNA methylation in the mammalian genome refers to the methylation of cytosine (5-methyl-cytosine, m5C) within a CpG dinucleotide. • CpG is a palindromic sequence, and typically the cytosines in both strands are methylated. •It is estimated that approximately 80% of C residues within CpG dinucleotides are methylated. •As m5C can undergo spontaneous deamination to thymine, methylated CpG dinucleotides are hot spots for mutation and are slowly eliminated during evolution. Therefore, in large parts of the mammalian genome, CpG dinucleotides occur at a much lower frequency than expected from the relative frequency of C and G residues. 2

Item Type:Teaching Resource
زبان سند : انگلیسی
نویسنده :سید سعید حسینی اصل
کلیدواژه ها (انگلیسی):Epigenetics , DNA , Genomic
Subjects:QU Biochemistry
QZ Pathology
WB Practice of Medicine
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:4257
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:20 Mar 1392 11:21
Last Modified:20 Mar 1392 11:21

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