ژن درمانی خودکشی

حسینی اصل, سید سعید (1392) ژن درمانی خودکشی. [Teaching Resource]

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Suicide Gene Therapy

English Abstract

Chemotherapy is widely used with surgery and radiotherapy for the treatment of malignant disease. Selectivity of most drugs for malignant cells remains elusive. Unfortunately, an insufficient therapeutic index, a lack of specificity, and the emergence of drug-resistant cell subpopulations often hamper the efficacy of drug therapies. A number of specific difficulties are associated with the treatment of solid tumors: Access of drugs to cancer cells is often limited by poor, unequal vascularization and areas of necrosis. The histological heterogeneity of the cell population within the tumor is another major drawback. Attempts to target therapies to tumors have been addressed by using prodrugs activated in tumors by elevated selective enzymes. An alternative strategy is using antibodies to target tumors with foreign enzymes that subsequently activate prodrugs. One approach aimed at enhancing the selectivity of cancer chemotherapy for solid tumors relies on the application of gene therapy technologies. Gene therapies are techniques for modifying the cellular genome for therapeutic benefit. In cancer gene therapy, both malignant and nonmalignant cells may be suitable targets.

Item Type:Teaching Resource
زبان سند : انگلیسی
نویسنده :سید سعید حسینی اصل
کلیدواژه ها (انگلیسی):Suicide , Gene Therapy
Subjects:QZ Pathology
WB Practice of Medicine
WM Psychiatry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:4264
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:28 Mar 1392 09:04
Last Modified:28 Mar 1392 09:04

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