RNA مداخله گر

Title

RNA interference

English Abstract

RNA silencing is a broad term that has been used to describe RNA interference (RNAi) in animals, posttranscriptional gene silencing in plants, and quelling in fungi, which are all phenotypically different but mechanistically similar forms of RNAi RNAi is a natural process in which double-stranded RNA (dsRNA) or hairpin RNA is cleaved by RNaseIII-type enzyme called Dicer into small interfering RNA (siRNA) duplex of 21–26 nucleotides, which then direct sequence-specific, homology-dependent, posttranscriptional gene silencing by binding to its complementary RNA and triggering its elimination through degradation or by inducing translational inhibition

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