يافته هاي پاتولوژيكي تاخيري در راديوتراپي قفسه سينه: يك مطالعه مقدماتي در مدل حيواني

تکاور, عباس and مينایی, باقر and حدادی, غلامحسن and خوئی, سمیده and رفاهی, سهیلا and بهروزكيا, ژاله and پورعیسی, مسعود and غمامی, گیتی (1392) يافته هاي پاتولوژيكي تاخيري در راديوتراپي قفسه سينه: يك مطالعه مقدماتي در مدل حيواني. Life Science Journal - Acta Zhengzhou University Overseas Edition ــ 10 (7s). pp. 583-585. شاپا 1097-8135

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Official URL: http://www.lifesciencesite.com/lsj/life1007s


Late histopathological findings in the thoracic irradiation: A preliminary study in the animal model

English Abstract

Purpose: To investigate late histopathological alterations in rat lung cells following single-dose of irradiation. Methods and materials: The thoracic cage of entire lung of Wistar rats was exposed to 17 Gy 60Co gamma rays. The animals were sacrificed at 32 weeks after irradiation. The lungs were dissected and blinded histopathological evaluation was performed. Results: When the lungs were removed at 32 weeks after whole thoracic irradiation, histopathologically inflammation and mononuclear infiltrate in the interstitium, Intraalveolar hemorrhages, dilatation in the alveolar space with alterations of the alveolar wall, congestion of the dilated vessels, foam and dust cells and superimposed collagen were noted in all animals. Conclusion: At the end of the histological examination, it was seen that all of the animals had severe superimposed collagen and a large fibrous area. We conclude that, in the rat lung model with single dose of 17 Gy, the most interesting finding in this study was in the expression of late fibrosis.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :عباس تکاور
نویسنده :باقر مينایی
نویسنده :غلامحسن حدادی
نویسنده :سمیده خوئی
نویسنده مسئول :سهیلا رفاهی
نویسنده :ژاله بهروزكيا
نویسنده :مسعود پورعیسی
نویسنده :گیتی غمامی
Additional Information:ویژه نامه7 indexed in: scopus , Google Scholar
Uncontrolled Keywords:فيبروز ريوي ، هيستو پاتولوژي ريه ، راديوتراپي قفسه سينه
کلیدواژه ها (انگلیسی):Thoracic irradiation , Lung histopathology , Pulmonary fibrosis
Subjects:QZ Pathology
WF Respiratory System
WN Radiology . Diagnostic Imaging
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Medical Physics
ID Code:4281
Deposited By: Dr Soheila Refahi
Deposited On:23 Mar 1392 08:38
Last Modified:24 Dec 1399 09:35

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