اثر متیل سولفونیل متان بر آسیب کبدی و ریوی ناشی از پاراکوات

امیرشاهرخی, کیوان and بهلولی, شهاب (1392) اثر متیل سولفونیل متان بر آسیب کبدی و ریوی ناشی از پاراکوات. Inflammation ــ 36 (5). pp. 1111-1121. شاپا 0360-3997

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Official URL: http://link.springer.com/article/10.1007%2Fs10753-...


Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice

English Abstract

Methylsulfonylmethane (MSM) is a natural organosulfur compound that exhibits antioxidative and anti-inflammatory effects. This study was carried out to investigate the effect of MSM on paraquat (PQ)-induced acute lung and liver injury in mice. A single dose of PQ (50 mg/kg, i.p.) induced acute lung and liver toxicity. Mice were treated with MSM (500 mg/kg/day, i.p.) for 5 days. At the end of the experiment animals were euthanized and lung and liver tissues were collected for histological and biochemical analysis. Tissue samples were used to determine malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) and tumor necrosis factor-α (TNF-α) levels. Blood samples were used to measure plasma alanine transaminase (ALT), γ-glutamyl transferase (GGT) and alkaline phosphatase (ALP). Histological examination indicated that MSM decreased lung and liver damage caused by paraquat. Biochemical results showed that MSM treatment significantly reduced tissue levels of MDA, MPO and TNF-α, while increased the levels of SOD, CAT and GSH compared with paraquat group. MSM treatment also significantly reduced plasma levels of ALT, GGT and ALP. These findings suggest that MSM as a natural product attenuates PQ-induced pulmonary and hepatic oxidative injury.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :شهاب بهلولی
Additional Information:Impact Factor 2012 : 2.457 Abstracted/Indexed in: Science Citation Index, Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, CAB International, Academic OneFile, Biological Abstracts, BIOSIS, CAB Abstracts, Current Contents/ Life Sciences, Elsevier Biobase, EMBiology, Expanded Academic, Global Health, Health Reference Center Academic, Highbeam, Index Copernicus, INIS Atomindex, International Bibliography of Book Reviews (IBR), International Bibliography of Periodical Literature (IBZ), OCLC, SCImago, Summon by Serial Solutions
Uncontrolled Keywords:متیل سولفونیل متان ؛ آسیب کبدی و ریوی ؛ پاراکوات
کلیدواژه ها (انگلیسی):Methylsulfonylmethane ; Paraquat toxicity ; Liver injury ; Lung injury
Subjects:QV pharmacology
WF Respiratory System
WI Digestive System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:4348
Deposited By: Dr Kivan Amir Shahrikhi
Deposited On:11 Jul 1392 11:10
Last Modified:07 Jul 1393 06:06

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