title

اثر تروگزروتین بر سطح آنزیم های آنتی اکسیدانی، استیل کولین استراز، تراکم نورونی هیپوکامپ و آپوپتوزیس در مدل آلزایمری بتا آمیلوئید

امانی, محمد and ببری, شیرین and محدث, گیسو and ابراهیمی, هادی (1392) اثر تروگزروتین بر سطح آنزیم های آنتی اکسیدانی، استیل کولین استراز، تراکم نورونی هیپوکامپ و آپوپتوزیس در مدل آلزایمری بتا آمیلوئید. [ research project ]

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Title

Effect of Troxerutin on antioxidant enzymes, AchE level and apoptosis in a β-amyloid model of Alzheimer’s disease.

English Abstract

Alzheimer׳s disease (AD) is a neurodegenerative disorder with a progressive cognitive decline and memory loss. Multiple pathogenetic factors including aggregated β-amyloid (Aβ), neurofibrillary tangles (NFTs), cholinergic dysfunction and oxidative stress are involved in AD. Aβ, a major constituent of the senile plaques, is a potent neurotoxic peptide and has a pivotal role in cognitive deficit and reduced synaptic plasticity in AD. In the present study we examined the protective effect of troxerutin, as a multipotent bioflavonoid, on Aβ (1–42)-induced impairment of evoked field potential in hippocampal DG neurons. Male Wistar rats were divided into four groups including Aβ (42–1), Aβ (1–42), Aβ (1–42) plus troxerutin and Aβ (42–1) plus troxerutin groups. Aβ was injected intracerebroventricularly (i.c.v.) into right lateral ventricle and after two weeks the evoked field potential recorded from perforant path-DG synapses to assess paired pulse paradigm and long term potentiation (LTP). Administration of Aβ (1–42) drastically attenuated the LTP of DG neurons, while there was no significant difference in evoked field potentials between Aβ (1–42) plus troxerutin group with respect to Aβ (42–1) group. This study revealed that troxerutin improves the synaptic failure induced by Aβ peptide and can be introduced as a promising multi-potent pharmacological agent in prevention or treatment of AD in the future.

Item Type: research project
زبان سند : فارسی
project status : اتمام یافته
سایر مجریان :محمد امانی
مجری اصلی :شیرین ببری
همکار طرح :گیسو محدث
همکار طرح :هادی ابراهیمی
تاریخ اتمام :16 March 1390
Subjects:QT physiology
QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:4366
Deposited By: Dr Mohammad Amani
Deposited On:03 Dec 1393 04:46
Last Modified:03 Dec 1393 04:47

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