title

اثر آمیلوئید بتای رسوب یافته بر شکل پذیری سیناپسی سلولهای گرانولی شکنج دندانه دار هیپوکامپ

ببری, شیرین and امانی, محمد and محدث, گیسو and علی همتی, علیرضا and ابراهیمی, هادی (1391) اثر آمیلوئید بتای رسوب یافته بر شکل پذیری سیناپسی سلولهای گرانولی شکنج دندانه دار هیپوکامپ. BioImpacts ــ 2 (4). pp. 189-94. شاپا 2228-5652

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Title

Effect of Aggregated β-Amyloid (1-42) on Synaptic Plasticity of Hippocampal Dentate Gyrus Granule Cells in Vivo.

English Abstract

Alzheimer's disease (AD) is a common neurodegenerative disorder in elderly people with an impairment of cognitive decline and memory loss. β-amyloid (Aβ) as a potent neurotoxic peptide has a pivotal role in the pathogenesis of AD. This disease begins with impairment in synaptic functions before developing into later neuro¬degeneration and neuronal loss. The aim of this study was to evaluate the synaptic plasticity and electrophysiological function of granule cells in hippocampal dentate gyrus (DG) after intracerebroventricular (i.c.v.) administration of aggregated Aβ (1-42) peptide in vivo.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :شیرین ببری
نویسنده مسئول :محمد امانی
نویسنده :گیسو محدث
نویسنده :علیرضا علی همتی
نویسنده :هادی ابراهیمی
Additional Information:Indexing in : Academic Journals Database , CAS: Chemical Abstracts Service , DOAJ, EBSCO , IndexCopernicus , Google Scholar , Islamic World Science Citation Center (ISC) , Magiran , Scopus
کلیدواژه ها (انگلیسی):β-Amyloid , Synaptic Plasticity , Dentate Gyrus , Long-Term Potentiation
Subjects:QT physiology
QV pharmacology
QZ Pathology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:4372
Deposited By: Dr Mohammad Amani
Deposited On:24 Apr 1392 12:00
Last Modified:10 Jan 1393 08:50

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