اثر تروگزروتین بر اختلال یادگیری و حافظه فضائی ناشی از آمیلوئید بتای 42-1 در موش بزرگ آزمایشگاهی

ببری, شیرین and امانی, محمد and محدث, گیسو and علی همتی, علیرضا and ابراهیمی, هادی (1391) اثر تروگزروتین بر اختلال یادگیری و حافظه فضائی ناشی از آمیلوئید بتای 42-1 در موش بزرگ آزمایشگاهی. Neurophysiology ــ 44 (5). pp. 387-393. شاپا 0090-2977

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Official URL: http://link.springer.com/article/10.1007%2Fs11062-...


Protective Effects of Troxerutin on β-Amyloid (1-42)-Induced Impairments of Spatial Learning and Memory in Rats

English Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder with a progressive cognitive decline and memory loss characterized pathologically by the appearance of senile plaques and neurofibrillary tangles (NFTs). β-amyloid peptide protein (Aβ) is a potent neurotoxic peptide and a major constituent of the senile plaques that leads to neural dysfunction. In the present study we examined the protective effect of Troxerutin, a natural bioflavonoid, on β-amyloid (1-42)-Induced impairment of learning and memory. Male Wistar rats (300–350 g) were divided into six groups: sham, Aβ (1-42), Aβ (42-1) and Aβ (1-42) injection plus treatment with three different doses of Troxerutin (50, 150, 300 mg/kg) for eight consecutive days. Aβ was injected intracerebroventricularly (i.c.v.) into right lateral ventricle and eight days after i.c.v. injection Morris water maze task was performed to assess spatial learning and memory. Our results showed that Troxerutin at lower doses (50, 150 mg/kg) had not any significant effect on Aβ induced impairment of memory performance, but the dose of 300 mg/kg of Troxerutin effectively protected Aβ induced impairment of spatial learning and memory in Aβ (1-42) treated animals. The improving effects of Troxerutin may be partly due to its antioxidant, anti-inflammatory activities and modification in cholinergic system.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :شیرین ببری
نویسنده مسئول :محمد امانی
نویسنده :گیسو محدث
نویسنده :علیرضا علی همتی
نویسنده :هادی ابراهیمی
Additional Information:Impact factor: 0.384 Indexed in : Science Citation Index Expanded (ISI) SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, AGRICOLA, Biological Abstracts, BIOSIS, Current Abstracts, Gale, OCLC, SCImago, Summon by Serial Solutions
کلیدواژه ها (انگلیسی):Troxerutin , spatial learning and memory , β-Amyloid , Alzheimer's disease
Subjects:QT physiology
QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:4374
Deposited By: Dr Mohammad Amani
Deposited On:24 Apr 1392 12:10
Last Modified:10 Jan 1393 08:49

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