اثر تزریق داخل بطنی گرلین بر حافظه فضایی بدنبال صرع ایجاد شده با پنتیلن تترازول در موش بزرگ آزمایشگاهی

ببری, شیرین and امانی, محمد and محدث, گیسو and میرزائی, فریبا and محمودی, فریبا (1392) اثر تزریق داخل بطنی گرلین بر حافظه فضایی بدنبال صرع ایجاد شده با پنتیلن تترازول در موش بزرگ آزمایشگاهی. Neuropeptides ــ 47 (5). pp. 355-360. شاپا 0143-4179

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Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats

English Abstract

Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including control, saline, ghrelin (0.3, 1.5 or 3nmol) and pentylenetetrazol (PTZ, 50mg/kg, i.p.) plus saline or ghrelin (0.3, 1.5 or 3nmol). All groups were trained in Morris water maze (MWM) for two consecutive days. Our results showed that ghrelin significantly improves spatial memory at the doses of 1.5 or 3nmol (P<0.05) in normal rats. We also demonstrated the significant impairment of spatial memory in PTZ group (P<0.05). Intrahippocampal injection of ghrelin at the dose of 3nmol significantly improved spatial memory in PTZ+gh group compared to PTZ group (P<0.05). These findings suggest that ghrelin as a neuropeptide can improve spatial memory in PTZ-treated rats.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :شیرین ببری
نویسنده مسئول :محمد امانی
نویسنده :گیسو محدث
نویسنده :فریبا میرزائی
نویسنده :فریبا محمودی
Additional Information:Impact Factor: 2.067 , Indexing in : ADONIS , BIOSIS , Cambridge Scientific Abstracts , Chemical Abstracts , Current Awareness in Biological Sciences , Current Contents/Life Sciences , EMBASE , Excerpta Medica , MEDLINE , Neuroscience Citation Index , Reference Update , Science Citation Index , Scisearch , Scopus
کلیدواژه ها (انگلیسی):Ghrelin , Pentylenetetrazol (PTZ) , Spatial memory , Hippocampus , Morris water maze
Subjects:QT physiology
QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:4376
Deposited By: Dr Mohammad Amani
Deposited On:09 Aug 1392 12:15
Last Modified:10 Jan 1393 08:47

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