اثر ضد التهابی تالیدوماید بر آسیب ریوی ناشی از پاراکوات

امیرشاهرخی, کیوان (1392) اثر ضد التهابی تالیدوماید بر آسیب ریوی ناشی از پاراکوات. International Immunopharmacology ــ 17 (2). pp. 210-215. شاپا 1567-5769


Official URL: http://www.sciencedirect.com/science/article/pii/S...


Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice

English Abstract

Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity. Paraquat (PQ) poisoning causes severe lung injury. PQ-induced pulmonary inflammation and fibrosis are due to its ability to induce oxidative stress, inflammatory and fibrotic reactions. This study was designed to evaluate the anti-inflammatory and anti-fibrotic effect of thalidomide on PQ-induced lung damage in a mouse model. Mice were injected with a single dose of PQ (20 mg/kg, i.p.), and treated with thalidomide (25 and 50 mg/kg/day, i.p.) for six days. Lung tissues were dissected out six days after PQ injection. The results showed that thalidomide ameliorated the biochemical and histological lung alterations induced by PQ. Thalidomide decreased production of inflammatory and fibrogenic cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and transforming growth factor (TGF)-β1. In addition thalidomide reduced myeloperoxidase (MPO), nitric oxide (NO), and hydroxyproline content in lung tissue. Taken together, the results of this study suggest that thalidomide might be valuable therapeutic drug in preventing the progression of PQ-induced pulmonary injury.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
Additional Information:Impact Factor: 2.376 Abstracting and Indexing: Science Citation Index Expanded , Cambridge Scientific Abstracts , Chemical Abstracts , Current Awareness in Biological Sciences , Current Contents (Life Sciences, Clinical Medicine) , Elsevier BIOBASE , Excerpta Medica , MEDLINE® , PASCAL/CNRS , SIIC Data Bases , Science Citation Index , Scopus
کلیدواژه ها (انگلیسی):Thalidomide ; Paraquat ; Lung injury ; Cytokines ; Nitric oxide
Subjects:QV pharmacology
WF Respiratory System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:4379
Deposited By: Dr Kivan Amir Shahrikhi
Deposited On:21 Apr 1392 19:53
Last Modified:07 Jul 1393 06:07

Repository Staff Only: item control page

Document Downloads

More statistics for this item...