تاثیر پره گابالین خوراکی بر درد بعد از عمل جراحی ارتوپدی اندام تحتانی: یک مطالعه دوسو

اخوان اکبری, قدرت ، انتظاری, مسعود ، عیسی زاده فر, خاطره ، میرزارحیمی, تیبا (1392) تاثیر پره گابالین خوراکی بر درد بعد از عمل جراحی ارتوپدی اندام تحتانی: یک مطالعه دوسو. Perspectives in Clinical Research ــ 4 (3). ص.ص.165-168. شاپا 2229-3485

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آدرس اینترنتی رسمی : http://www.picronline.org/article.asp?issn=2229-34...

عنوان انگليسي

The effects of oral pregabalin on post-operative pain of lower limb orthopedic surgery: A double-blind, placebo-controlled trial

خلاصه انگلیسی

Background: Post-operative pain is one of the problems, wherein lack of control on it has many side-effects such as tachycardia, hypertension, myocardial ischemia, decreased alveolar ventilation, and poor wound healing. Aims: In this study, we evaluated the pre-operative administration of pregabalin sufficiency and security in relieving post-operative pain after lower limb orthopedic surgery and reducing the need for opioids and their possible side-effects. Materials and Methods: This study is a randomized, double-blind clinical trial. It was performed on 60 patients under lower limb surgery by spinal anesthesia. Patients were randomly allocated to two groups, one group has received a 150 mg pregabalin capsule 2 h before surgery and the other group has received placebo as a control. In both groups at 2, 6, 12, and 24 h after surgery, the patients were evaluated and the pain score, the score of sedation, incidence of nausea and vomiting was recorded in the checklists. Then, the data were analyzed by SPSS v16. Results: Visual analog pain scores at all hours in pregabalin group significantly reduced compared to the placebo group ( P < 0.0001). Also, in the pregabalin group nausea and vomiting scores at all hours, sedation levels at 2 h and 6 h post-operatively, and pethidine consumption in all hours have significantly been reduced. Conclusion: A single pre-operative oral dose of pregabalin 150 mg is an effective method for reducing post-operative pain and pethidine consumption in patients undergoing orthopedic surgery.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :قدرت اخوان اکبری
نویسنده مسئول :مسعود انتظاری
نویسنده :خاطره عیسی زاده فر
نویسنده :تیبا میرزارحیمی
اطلاعات اضافی :Indexing in: Pubmed , google scholar
کلید واژه ها (انگلیسی):Pethidine , post-operative pain , pregabalin , visual analogue scale
موضوعات :QV فارماکولوژی
WE سیستم عضلانی اسکلتی
WO جراحی
بخش های دانشگاهی :دانشكده پزشكي > گروه بیهوشی، زنان و زایمان
کد شناسایی :4404
ارائه شده توسط : دکتر مسعود انتظاری اصل
ارائه شده در تاریخ :05 مرداد 1392 08:26
آخرین تغییر :10 فروردین 1393 09:03

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