اعطای کاهش استعداد ابتلا به سرطان معده در استان اردبیل توسط چند ریختی MTHFR C677T

حسینی اصل, سید سعید and پورفرضی, فرهاد and برزگر, ابوذر and مأذنی, محمد and فرهمند, نیما and نیاستی, الهام and یزدانبد, عباس and دیده ور, رضا and اخوان, هما and ملک زاده, رضا (1392) اعطای کاهش استعداد ابتلا به سرطان معده در استان اردبیل توسط چند ریختی MTHFR C677T. Turkish Journal of Gastroenterology ــ 24 (2). pp. 117-121. شاپا 1300-4948

Text - Published Version

Official URL: http://www.turkgastro.org/text.php?id=1461


Decrease in gastric cancer susceptibility by MTHFR C677T polymorphism in Ardabil Province, Iran

English Abstract

Background/aims: Gastric cancer, as the fourth most frequent malignancy worldwide, has the highest rate among cancer-related disorders in Ardabil province, located in North-West Iran. Methylene tetrahydrofolate reductase is one of the cancer susceptibility genes with considerable polymorphisms. Methylene tetrahydrofolate reductase C677T leads to a decrease of about 30% in its product activity and is reported to have an effect on cancer susceptibility. Materials and Methods: Methylene tetrahydrofolate reductase C677T genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism on peripheral blood DNA from 76 gastric cancer patients and 91 healthy controls. The statistical significance was calculated by logistic regression analysis. Results: The mean age was 64.2±11.1 and 62.1±9.8 years for cases and controls, respectively. Among tumors, 35.5% were diffuse type and others were intestinal. The frequency of genotypes was 61.8%, 32.9%, and 5.3% among cases and 45.1%, 50.6%, and 4.4% among controls for Ala/Ala, Ala/Val, and Val/Val, respectively. CT heterozygotes had lower susceptibility to gastric cancer (p=0.02). This relationship of significance was detected considering gender and age. Conclusions: It was found that T allele has a protective association with age in the Ardabil province. Key words: Gastric cancer, methylene tetrahydrofolate reductase, C677T, Ardabil

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :سید سعید حسینی اصل
نویسنده :فرهاد پورفرضی
نویسنده :ابوذر برزگر
نویسنده :محمد مأذنی
نویسنده :نیما فرهمند
نویسنده :الهام نیاستی
نویسنده :عباس یزدانبد
نویسنده :رضا دیده ور
نویسنده :هما اخوان
نویسنده :رضا ملک زاده
Additional Information:Impact Factor: 0.472 Indexing in: Science Citation Index Expanded , Pubmed ,
کلیدواژه ها (انگلیسی):Gastric cancer , methylene tetrahydrofolate reductase , C677T , Ardabil
Subjects:QY Clinical Pathology
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:4409
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:07 May 1392 09:53
Last Modified:10 Jul 1393 07:30

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