تعیین استرین های اکینوکوکوس گرانولوزوس جداشده از انسان و دام در استان اردبیل

پزشکی, علی and اخلاقی, لامع and شربت خوری, میترا and رزمجو, الهام and اورمزدی, هرمزد and محبعلی, مهدی and معمار, احمد رضا (1391) تعیین استرین های اکینوکوکوس گرانولوزوس جداشده از انسان و دام در استان اردبیل. Journal of Helminthology ــ 2012 . pp. 1-5. شاپا 0022-149X

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Genotyping of Echinococcus granulosus from domestic animals and humans from Ardabil Province, northwest Iran

English Abstract

Cystic echinococcosis is endemic in Iran, particularly in Ardabil Province, where it causes health and economic problems. The genetic pattern of Echinococcus granulosus has been determined in most parts of Iran, except in this area. In the present investigation, 55 larval isolates were collected from humans (11), sheep (19), goats (4) and cattle (21). For analysis of the genetic characteristics of E. granulosus isolates, DNA sequencing of mitochondrial cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes was applied. Fifty isolates were successfully analysed, with 92% (46) and 8% (4) identified as G1 and G3 genotypes, respectively. The sequence analyses of the isolates displayed nine characteristic profiles in cox1 sequences and eight characteristic profiles in nad1 sequences. Based on these results, the sheep strain (G1 genotype) was the most prevalent in humans, sheep, goats and cattle. The buffalo strain (G3 genotype) was not only demonstrated in sheep (1 isolate) and cattle (1 isolate), but also for the first time in two human isolates. These findings will provide information for local control of echinococcosis.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :علی پزشکی
نویسنده :لامع اخلاقی
نویسنده :میترا شربت خوری
نویسنده :الهام رزمجو
نویسنده :هرمزد اورمزدی
نویسنده :مهدی محبعلی
نویسنده مسئول :احمد رضا معمار
Additional Information:Impact Factor: 1.38 Indexed in: Science Citation Index Science Citation Index Expanded - Current Contents - Agriculture, Biology & Environmental Sciences , Zoological Record
کلیدواژه ها (انگلیسی):Echinococcus granulosus , genotype , human , domestic animals , Ardabil , Iran
Subjects:QX Parasitology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Parasitology
ID Code:4475
Deposited By: Dr Ali Pezeshki
Deposited On:15 May 1392 10:56
Last Modified:15 May 1392 10:56

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