title

دگزامتازون برای پیشگیری از لرز بعد از عمل: یک مقایسه دوسوکور تصادفی با پتدین

انتظاری, مسعود and عیسی زاده فر, خاطره (1392) دگزامتازون برای پیشگیری از لرز بعد از عمل: یک مقایسه دوسوکور تصادفی با پتدین. International Journal of Preventive Medicine ــ 4 (7). pp. 818-824. شاپا 2008-7802

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Title

Dexamethasone for Prevention of Postoperative Shivering: A Randomized Double-Blind Comparison with Pethidine

English Abstract

Background: Postoperative shivering is very common and followed by many problems such as increasing oxygen consumption, blood pressure, intracranial and intraocular pressure, and postoperative pain. Therefore, prevention of shivering is important, especially in elderly and ischemic heart disease patients. The goal of this study was to compare the effect of pethidine (meperidine), dexamethasone, and placebo on prevention of shivering. Methods: This double-blind clinical trial study was carried out on 120 patients who were candidates for surgery under general anesthesia. The patients were randomly divided into three groups. Induction and maintenance of anesthesia for all patients were similar. Temperature of patients was measured every 5 min interval. After induction, saline 0.9%, dexamethasone and pethidine were injected to groups a, b, and c, respectively. In recovery, patients were controlled for visible shivering. All data were statistically analyzed by analysis of variance (ANOVA) and Chi-square tests. Results: There were no signifi cant differences among three mentioned groups regarding gender, age, duration of surgery and anesthesia, extubation time, duration of recovery, and basic clinical characteristics. Nineteen cases (47.5%) of placebo group had postoperative shivering, whereas in dexamethasone group only four cases (10%) had shivering and the difference between the two groups was signifi cant. Also in pethidine group, 15 cases (37.5%) had shivering and the difference with placebo group was signifi cant (P value = 0.001). Conclusion: The present study showed that pethidine and dexamethasone are effective drugs for prevention of postoperative shivering in elective surgery and the effect of dexamethasone in preventing the postoperative shivering is better than pethidine.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مسعود انتظاری
نویسنده مسئول :خاطره عیسی زاده فر
Additional Information:indexed in: PubMed, PubMed Central, Scopus, EMBASE, WHO-EMRO Index Medicus, Scirus (Elsevier), ProQuest, NewJour, Islamic World Science Citation (ISC), Academic Search Complete EBSCO Publishing databases, Allied and Complementary Medicine Database (AMED), Ulrich's Periodicals Directory, Directory of Open Access Journals (DOAJ), Index Copernicus, NLM Catalog, PKP Open Archives Harvester, Geneva Foundation for Medical Education and Research, OpenJ-Gate, Biblioteca.net, Google Scholar, Scientific Information Database (SID), Magiran, Iranmedex and Iranvenex.
کلیدواژه ها (انگلیسی):Dexamethasone , general anesthesia , shivering , surgery , pethidine
Subjects:QV pharmacology
WO Surgery
Divisions:Faculty of Medicine > Department of Anesthesiology , Obstetrics & Gynecology
ID Code:4523
Deposited By: Dr Masood Entezariasl
Deposited On:23 May 1392 08:34
Last Modified:23 May 1392 08:35

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