بررسی خاصيت ضد باکتریایی پرده ‏های جنینی و مقایسه اثرات آنتی ‏باکتریال آن با تعدادی از آنتی‏ بیوتیک ‏های رایج

عنوان انگليسی

Evaluation of Anti-Bacterial Effects of Fetal Membranes and a Comparison with the Antibacterial Effects of Some Common Antibiotics

خلاصه انگلیسی

Background & Objectives: The spread of antibiotic resistance has brought forward a reason for studying alternative biological compounds. The limited studies conducted on fetal membranes have proposed some evidence of their antibacterial properties.The present study aimed to assess anti-bacterial properties of chorionic membranes in comparison with the effects of some common antibiotics. Methods: After spreading plates of species Escherichia coli, Streptococcus pyogenes, Shigella flexneri, Staphylococcus aureus, Bacillus cereus, Klebsiella pneumoniae and Pseudomonas aeruginosa, amniotic membranes and chorioamniotic membranes isolated from 24 healthy women who had given birth to a way of cesarean section were put on the plates. Also Antibiogram disks as positive control and the cord tissue as negative controls were used. After 24 h incubation at 37 ° C, the halo of growth around the membranes and antibiotic disks were studied and compared the results. Results: Antibacterial effects were found for chorionic membranes as halo of lack of bacterial, while for the same bacterial strains, apparent antibiotic resistance was revealed. Most anti-bacterial effects on the fetal membranes were shown for Streptococcus pyogenes, Staphylococcus aureus and Bacillus cereus. However, no halo of growth inhibition was observed for the bacterium Escherichia coli. Conclusion: This study confirms that in some cases the fetal membranes are capable to compete with anti-bacterial effects of some common antibiotics. So, the idea of using these membranes as a valuable supplement to antibiotics in order to expedite the treatment of dermal infections and infected wounds are strongly suggestive.

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