title

مطالعه و بررسی اثر پیش درمانی با متیل سولفونیل متان در جلوگیری از سمیت کبدی ایجاد شده توسط استامینوفن در موش سفید بزرگ آزمایشگاهی

بهلولی, شهاب and محمدی, پرهام سعداله and امیرشاهرخی, کیوان and میرزانژاد اصل, حافظ and یوسفی, محمد and محمدی - نی, امیر and چینی فروش, میرمهدی (1392) مطالعه و بررسی اثر پیش درمانی با متیل سولفونیل متان در جلوگیری از سمیت کبدی ایجاد شده توسط استامینوفن در موش سفید بزرگ آزمایشگاهی. Iranian Journal of Basic Medical Sciences ــ 16 (8). pp. 896-900. شاپا 2008-3866

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Title

Effect of Methylsulfonylmethane Pretreatment on Acetaminophen Induced Hepatotoxicity in Rats

English Abstract

Objective(s): Methylsulfonylmethane (MSM) is a sulfur-containing compound found in a wide range of human foods including fruits, vegetables, grains and beverages. In this study the effect of MSM pretreatment on acetaminophen induced liver damage was investigated. Materials and Methods: Male Sprague Dawley rats were pretreated with 100 mg/kg MSM for one week. On day seven rats were received acetaminophen (850 mg/kg, intraperitoneal). Twenty-four hours later, blood samples were taken to determine serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Tissue samples of liver were also taken for the determination of the levels of malondialdehyde (MDA); total glutathione (GSH), superoxide dismutase (SOD), and myeloperoxidase (MPO) activity together with histopathological observations. Results:High dose of acetaminophen administration caused a significant decrease in the GSH level of the liver tissue, which was accompanied with a decrease in SOD activity and increases in tissue MDA level and MPO activity. Serum ALT, AST levels were also found elevated in the acetaminophen-treated group. Pretreatment with MSM for one week was significantly attenuated all of these biochemical indices. Conclusion: Our findings suggest that MSM pretreatment could alleviate hepatic injury induced by acetaminophen intoxication, may be through its sulfur donating and antioxidant effects.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :شهاب بهلولی
نویسنده :پرهام سعداله محمدی
نویسنده :کیوان امیرشاهرخی
نویسنده :حافظ میرزانژاد اصل
نویسنده :محمد یوسفی
نویسنده :امیر محمدی - نی
Additional Information:IF: 0.243 Indexed in: ISI, Scopus, PubMed/PMC, Embase
Uncontrolled Keywords:سمیت کبدی ، متیل سولفونیل متان ، مسمومیت ، آنتی اکسیدان،
کلیدواژه ها (انگلیسی):Acetaminophen , Anti-oxidant , Hepatotoxicity , Methylsulfonylmethane , Poisoning
Subjects:QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pathology
Faculty of Medicine > Department of Basic Sciences > Department of Parasitology
Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:4610
Deposited By: Dr Shahab Bohlooli
Deposited On:14 Jun 1392 12:18
Last Modified:03 May 1400 09:28

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