نقش فراموش شده قلیان و تریاک در سرطان معده: مطالعه کوهورت در مورد عوامل خطر

سجادی, علیرضا and درخشان, محمدحسین and یزدانبد, عباس and بوریری, مجید and پارساییان , محبوبه and بابایی, مسعود and علیمحمدیان , معصومه and صمدی, فاطمه and اعتمادی, آرش and پورفرضی, فرهاد and احمدی, عماد and دلاوری, علیرضا and اسلامی, فرهاد and فرزادفر, فرشاد and ستوده, مسعود and نیک منش, آرش and علیزاده, بهروز and اچ دی بوک, گیرتودیا and ملک زاده, رضا (1392) نقش فراموش شده قلیان و تریاک در سرطان معده: مطالعه کوهورت در مورد عوامل خطر. international journal of cancer ــ 134 (1). pp. 181-188. شاپا 0020-7136

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ijc.283...


Neglected role of hookah and opium in gastric carcinogenesis: A cohort study on risk factors and attributable fractions

English Abstract

A recent study showed an association between hookah/opium use and gastric cancer but no study has investigated the relationship with gastric precancerous lesions. We examined the association between hookah/opium and gastric precancerous lesions and subsequent gastric cancer. In a population-based cohort study, 928 randomly selected, healthy, Helicobacter pylori-infected subjects in Ardabil Province, Iran, were followed for 10 years. The association between baseline precancerous lesions and lifestyle risk factors (including hookah/opium) was analyzed using logistic regression and presented as odds ratios (ORs) and 95% confidence intervals (CIs). We also calculated hazard ratios (HRs) and 95% CIs for the associations of lifestyle risk factors and endoscopic and histological parameters with incident gastric cancers using Cox regression models. Additionally, the proportion of cancers attributable to modifiable risk factors was calculated. During 9,096 person-years of follow-up, 36 new cases of gastric cancer were observed (incidence rate: 3.96/1,000 persons-years). Opium consumption was strongly associated with baseline antral (OR: 3.2; 95% CI: 1.2-9.1) and body intestinal metaplasia (OR: 7.3; 95% CI: 2.5-21.5). Opium (HR: 3.2; 95% CI: 1.4-7.7), hookah (HR: 3.4; 95% CI: 1.7-7.1) and cigarette use (HR: 3.2; 95% CI: 1.4-7.5), as well as high salt intake, family history of gastric cancer, gastric ulcer and histological atrophic gastritis and intestinal metaplasia of body were associated with higher risk of gastric cancer. The fraction of cancers attributable jointly to high salt, low fruit intake, smoking (including hookah) and opium was 93% (95% CI: 83-98). Hookah and opium use are risk factors for gastric cancer as well as for precancerous lesions. Hookah, opium, cigarette and high salt intake are important modifiable risk factors in this high-incidence gastric cancer area.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :علیرضا سجادی
نویسنده :عباس یزدانبد
نویسنده :فرهاد پورفرضی
نویسنده مسئول :رضا ملک زاده
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کلیدواژه ها (انگلیسی):Helicobacter pylori, gastric cancer, hookah, opium, precancerous lesions, smoking
Subjects:QZ Pathology
WF Respiratory System
WI Digestive System
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:4619
Deposited By: MS Soghra Golmaghani
Deposited On:27 Jul 1392 10:40
Last Modified:17 Aug 1394 09:51

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