گزارش اولین مورد عفونت سالمونلایی مقاوم به سیپروفلوکساسین و اینتگرون مثبت در یک کودک در ایران

عنوان انگليسی

First Ciprofloxacin Resistant Salmonella Infection Acquired by a Child in Iran

خلاصه انگلیسی

Background & Objectives: The frequency of multidrug-resistance (MDR) among Salmonella isolates has increased dramatically. Here we report the first case of ciprofloxacin-resistant Salmonella infection in a child in Iran. Methods: Antimicrobial resistance profile was determined according to the Clinical and Laboratory Standards Institute. A double disk synergy test was used for the production of Extended-Spectrum β-lactamases (ESBLs). PCR assays were carried out to detect blaTEM, blaSHV and blaCTX-M beta lactamase genes.The presence of class 1 integrons was investigated by PCR assays. Results: The Salmonella enteritidis isolate from the child was ciprofloxacin and extended-spectrum cephalosporins resistant and found to carry the blaCTX-M betalactamase gene and class 1 integrons, suggests that antimicrobial resistance determinants may to be located on the same genetic unit as the class 1 integrons identified here. Conclusion: Resistance to ciprofloxacin and extended-spectrum cephalosporins, the drugs of choice for treating invasive salmonellosis especially in children is a public health problem.

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