بررسی ژنوتایپ ویروس هپاتیت B و موتاسیون درنوکلئوتیدهای 1762 و 1764 ژن X در افراد مبتلا به هپاتیت B مزمن در استان گلستان

ژند, ساره and مرادی, عبدالوهاب and قائمی, امیر and بازوری, مسعود and جاوید, سیده ناعمه and تبرائی, علیجان (1391) بررسی ژنوتایپ ویروس هپاتیت B و موتاسیون درنوکلئوتیدهای 1762 و 1764 ژن X در افراد مبتلا به هپاتیت B مزمن در استان گلستان. در: The 13th Iranian & The Second International Congress of Microbiology, July 14 – 16, 2012, Ardabil - Iran.

Text - Published Version

Official URL: http://congress.arums.ac.ir/index.php/IICM/5/sched...


Study of Hepatitis B Virus Genotypes and Mutation in 1762 & 1764 Nucleotides of X Gene in Chronic HBV Patients from Golestan Provience - Iran

English Abstract

Background & Objectives: More than 350 million people are chronic carriers of HBV and many of them develop progressive diseases, including cirrhosis and hepatocellular carcinoma. Many of those infected develop persistent disease and a proportion goes on to develop liver failure and cancer. Researchers showed that double mutations of the x gene at position 1762 and 1764, have been found in chronic hepatitis B. These mutations were proposed to be associated with fulminant hepatitis B increased risk of hepatocellular carcinoma. This project aimed to investigate mutation in the x gene region of HBV infected patients in Golestan province- Iran. Methods: 100 patients were entered in this study. Hepatitis B viral DNAwas extracted from plasma and PCR was performed using specific primers. Direct sequencing and alignment of x gene were applied using reference sequence from Gene Bank database (Okamoto, 1988; Accession number AB033559 and GU938305). Results: Among the chronic HBV patients 51% was male and 49% was female. The results showed that 49% of patients had A1762T, G1764A mutations changing AGG to stop codon TGA. 27% and 24% of cases were showed mutation only in A1762T and G1764A positions respectively. Conclusion: This study was shown presence of x gene mutation in HBV infected people in Golestan province-Iran. The rate of mutation in two positions 1762 and 1764 of HBV genotype D x gene was higher than the average rate of the world (34%).

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده اول :ساره ژند
نویسنده مسئول :علیجان تبرائی
کلیدواژه ها (انگلیسی):HBV ; x Gene ; Mutation ; Genotype ; Iran
Subjects:QW Microbiology and Immunology
WC Communicable Diseases
WI Digestive System
Divisions:Vice Chancellor for Research and Technology > Deputy for Research and Technology management and Medical Information > University of Management Conferences and Congresses
ID Code:4715
Deposited By: MS Soghra Golmaghani
Deposited On:08 Jul 1392 12:02
Last Modified:08 Jul 1392 12:02

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