شیوع سیگنالهای میکروآمبولیک در سکته های مغزی حاد در حوزه شریان مغزی میانی که با آسپرین یا کلوپیدوگرل درمان شده اند

هاشمیلر, مازیار and فرهودی, مهدی and سمانه, حسینی and مشایدی, هانیه and سوادی اسکویی, داریوش and اسکندراوغلی, بهزاد and ریخته گر, رضا (1390) شیوع سیگنالهای میکروآمبولیک در سکته های مغزی حاد در حوزه شریان مغزی میانی که با آسپرین یا کلوپیدوگرل درمان شده اند. Iranian Journal of Neurology ــ 10 (2-1). pp. 16-18. شاپا 2008-384X

Text - Published Version

Official URL: http://ijnl.tums.ac.ir/index.php/ijnl/article/view...


Frequency of microembolic signals in patients with acute ischemic stroke in middle cerebral artery territory treated with aspirin or clopidogrel

English Abstract

Background: In patients with acute stroke and middle cerebral artery (MCA) stenosis, microembolic signals (MES) can predict further cerebral ischemia. Therefore, this study was designed to evaluate the prevalence of MES by transcranial Doppler (TCD) in patients with MCA stenosis under treatment of aspirin or clopidogrel. Methods: A randomized clinical trial was performed on 40 patients with acute ischemic stroke in MCA territory. They were randomly allocated in two groups that treated with aspirin (80 mg daily) or clopidogrel (75 mg daily). Clinical and diagnostic work up was included evaluation of cerebrovascular risk factors, echocardiography, carotid color Doppler and brain imaging. TCD was performed between day 3 and 7 after symptoms onset to detect MES. All high intensity transient signals (HITS) were saved and analyzed offline. Results: Carotid stenosis was found in 13 (65%) patients of aspirin group and 12 (60%) of clopidogrel group. Four (30.8%) of aspirin group and 5 (41.7) of clopidogrel group had stenosis between 10%-50%. One patient in each group had more than 50% stenosis and the remainder had less than 10%. There was no significant difference between two groups. MES was detected in 6 (30%) of patients treated with aspirin and 4 (20%) of those treated with clopidogrel. It showed no statistically significant differences (P-value= 0.46). Conclusion: Our results indicate a similar effect of aspirin and clopidogrel on frequency of MES in patients with MCA territory ischemic stroke.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مازیار هاشمیلر
نویسنده :مهدی فرهودی
نویسنده :حسینی سمانه
نویسنده مسئول :هانیه مشایدی
نویسنده :داریوش سوادی اسکویی
نویسنده :بهزاد اسکندراوغلی
نویسنده :رضا ریخته گر
Additional Information:Indexed in : Directory of Research Journal Indexing (DRJI), Electronic Journals Library, Google Scholar, LocatorPlus, Scientific Information Database (SID),
کلیدواژه ها (انگلیسی):Microembolic Signals , Transcranial Doppler, Middle Cerebral Artery, Aspirin; Clopidogrel
Subjects:QV pharmacology
WL Nervous system
WO Surgery
Divisions:Faculty of Medicine > Department of Surgery
ID Code:4748
Deposited By: Dr Masood Entezariasl
Deposited On:27 Jul 1392 14:15
Last Modified:07 Jul 1393 05:32

Repository Staff Only: item control page

Document Downloads

More statistics for this item...