کاربرد گرلین سرم به عنوان جانشینی برای کارسینوژنز محاطی سرطانهای گوارشی فوقانی

سجادی, علیرضا ، یزدانبد, عباس ، لی, یه اونگ یه ، بوریری, مجید ، صمدی, فاطمه ، علیزاده, زیاد ، اسلامی, فرهاد ، فایف, وی ، بابایی, مسعود ، نمازی, محمد جلال ، گوینگ, جیمز جی ، ستوده, مسعود ، اچ دی بوک, گیرتودیا ، ملک زاده, رضا ، درخشان, محمدحسین (1392) کاربرد گرلین سرم به عنوان جانشینی برای کارسینوژنز محاطی سرطانهای گوارشی فوقانی. PloS ONE ــ 8 (9). ص.ص.1-7. شاپا 1932-6203

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آدرس اینترنتی رسمی : http://www.plosone.org/article/info%3Adoi%2F10.137...

عنوان انگليسي

Serum Ghrelin; A New Surrogate Marker of Gastric Mucosal Alterations in Upper Gastrointestinal Carcinogenesis

خلاصه انگلیسی

Background A few studies have indicated inverse relationships between serum ghrelin and gastric and esophageal cancers but those associations have been restricted to specific populations, including smokers and overweight individuals. We examined the association between ghrelin and gastroesophageal cancers and atrophic gastritis in a population-based setting. Methods In total 220 gastroesophageal cancers, comprising non-cardia and cardia gastric cancer, esophageal adenocarcinoma, esophageal squamous cell carcinoma (SCC) and age and gender-matched controls were recruited. Serum ghrelin, pepsinogen I/II ratio (PGI/II) and anti-H.pylori IgG antibodies were measured. Relationships between ghrelin and gastroesophageal cancers, after adjustment for PGI/II ratio, H.pylori status and smoking, were tested using logistic regression. Furthermore, in 125 endoscopically normal volunteers, with and without histological atrophic gastritis, the relationship with ghrelin was compared. Results Serum ghrelin (lowest vs. highest quintile) was inversely associated with gastric cancer: OR (95% CI) 8.71 (1.70–44.59) for cardia and 6.58 (1.26–34.46) for non-cardia cancer. Lower serum ghrelin was also associated with esophageal SCC: OR (95% CI) 5.69 (1.36–23.78), but not with esophageal adenocarcinoma. A similar association was observed between gastric cancer (cardia and non-cardia) and esophageal SCC when serum ghrelin was analysed as a continuous scaled variable. In endoscopically-normal volunteers, extensive atrophic gastritis was associated with low serum ghrelin [OR (95% CI) 0.25 (0.10–0.64)]. Conclusion Inverse associations between ghrelin and some gastroesophageal cancers suggest a potential role for serum ghrelin as a biomarker of upper gastrointestinal cancers and atrophic gastritis. In areas with a high incidence of gastric and/or esophageal cancer, screening might be more effectively targeted to individuals with low serum ghrelin in addition to the PGI/II ratio.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :علیرضا سجادی
نویسنده :عباس یزدانبد
نویسنده مسئول :محمدحسین درخشان
اطلاعات اضافی :Impact Factor: (2013) 3.534 indexed in: ISI, PubMed, MEDLINE, PubMed Central, Science Citation Index Expanded , Scopus, Web of Science, Google Scholar, the Chemical Abstracts Service (CAS), EMBASE, AGRICOLA, PsycINFO, Zoological Records, FSTA (Food Science and Technology Abstracts), GeoRef, and RefAware ,
کلید واژه ها (انگلیسی):Gastrointestinal , Carcinogenesis , Gastric , Serum Ghrelin
موضوعات :QZ آسیب شناسی
WI سیستم گوارشی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :4771
ارائه شده توسط : دکتر شهرام حبیب زاده
ارائه شده در تاریخ :21 مهر 1392 14:23
آخرین تغییر :18 آبان 1394 07:58

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