کاربرد گرلین سرم به عنوان جانشینی برای کارسینوژنز محاطی سرطانهای گوارشی فوقانی

سجادی, علیرضا and یزدانبد, عباس and لی, یه اونگ یه and بوریری, مجید and صمدی, فاطمه and علیزاده, زیاد and اسلامی, فرهاد and فایف, وی and بابایی, مسعود and نمازی, محمد جلال and گوینگ, جیمز جی and ستوده, مسعود and اچ دی بوک, گیرتودیا and ملک زاده, رضا and درخشان, محمدحسین (1392) کاربرد گرلین سرم به عنوان جانشینی برای کارسینوژنز محاطی سرطانهای گوارشی فوقانی. PloS ONE ــ 8 (9). pp. 1-7. شاپا 1932-6203

Text - Published Version

Official URL: http://www.plosone.org/article/info%3Adoi%2F10.137...


Serum Ghrelin; A New Surrogate Marker of Gastric Mucosal Alterations in Upper Gastrointestinal Carcinogenesis

English Abstract

Background A few studies have indicated inverse relationships between serum ghrelin and gastric and esophageal cancers but those associations have been restricted to specific populations, including smokers and overweight individuals. We examined the association between ghrelin and gastroesophageal cancers and atrophic gastritis in a population-based setting. Methods In total 220 gastroesophageal cancers, comprising non-cardia and cardia gastric cancer, esophageal adenocarcinoma, esophageal squamous cell carcinoma (SCC) and age and gender-matched controls were recruited. Serum ghrelin, pepsinogen I/II ratio (PGI/II) and anti-H.pylori IgG antibodies were measured. Relationships between ghrelin and gastroesophageal cancers, after adjustment for PGI/II ratio, H.pylori status and smoking, were tested using logistic regression. Furthermore, in 125 endoscopically normal volunteers, with and without histological atrophic gastritis, the relationship with ghrelin was compared. Results Serum ghrelin (lowest vs. highest quintile) was inversely associated with gastric cancer: OR (95% CI) 8.71 (1.70–44.59) for cardia and 6.58 (1.26–34.46) for non-cardia cancer. Lower serum ghrelin was also associated with esophageal SCC: OR (95% CI) 5.69 (1.36–23.78), but not with esophageal adenocarcinoma. A similar association was observed between gastric cancer (cardia and non-cardia) and esophageal SCC when serum ghrelin was analysed as a continuous scaled variable. In endoscopically-normal volunteers, extensive atrophic gastritis was associated with low serum ghrelin [OR (95% CI) 0.25 (0.10–0.64)]. Conclusion Inverse associations between ghrelin and some gastroesophageal cancers suggest a potential role for serum ghrelin as a biomarker of upper gastrointestinal cancers and atrophic gastritis. In areas with a high incidence of gastric and/or esophageal cancer, screening might be more effectively targeted to individuals with low serum ghrelin in addition to the PGI/II ratio.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :علیرضا سجادی
نویسنده :عباس یزدانبد
نویسنده مسئول :محمدحسین درخشان
Additional Information:Impact Factor: (2013) 3.534 indexed in: ISI, PubMed, MEDLINE, PubMed Central, Science Citation Index Expanded , Scopus, Web of Science, Google Scholar, the Chemical Abstracts Service (CAS), EMBASE, AGRICOLA, PsycINFO, Zoological Records, FSTA (Food Science and Technology Abstracts), GeoRef, and RefAware ,
کلیدواژه ها (انگلیسی):Gastrointestinal , Carcinogenesis , Gastric , Serum Ghrelin
Subjects:QZ Pathology
WI Digestive System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:4771
Deposited By: Dr Shahram Habibzadeh
Deposited On:21 Jul 1392 14:23
Last Modified:18 Aug 1394 07:58

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