بررسی اثر ضد میکروبی کلی سین بر روی باکتری ٍE.coli k99 در بچه موش

Title

Colicin as a Bioprotective Agent for Control of E. coli K99

English Abstract

Background & Objectives: K99 pilus antigen is one of the major adherence factors found on enterotoxigenic Escherichia coli (ETEC) of neonatal calves. It causes severe diarrhea in newborn calves via the production of heat-stable enterotoxin (STa).With increasing concern over the spread of antimicrobial resistance, the development of alternative to conventional antibiotics such as colicin is urgently needed. Colicin is an antimicrobial peptide produced by one strain of E. coli to suppress the growth of other strains of E.coli. The aim was to examine the control of E.coli k99 by the oral administration of colicinogenic E.coli (CEC) as probiotics in an infant mouse model. Methods: The first control group was fed E.coli K99 and the second just CEC. The test group received E.coli K99 after oral administration of CEC at the variation time. Results: Study of the results delineated that CEC has inhibitory effect against E.coli k99 and prevented death caused by STa of E.coli k99 in infant mice. Conclusion : The data presented here support this claim that CEC play a significant role against E.coli k99. Furthermore, the study suggested colicin warrants further evaluation as a potential alternative to conventional antibiotics for use to control of E.coli k99.

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