بررسی شیوع میکروبی و مقاومت آنتی بیوتیکی در بیماران فیبروز کیستی در تهران

اکبری, رضا and والی, پریسا and سیف پور, مریم and شاهچراغی, فرشته (1391) بررسی شیوع میکروبی و مقاومت آنتی بیوتیکی در بیماران فیبروز کیستی در تهران. در: The 13th Iranian & The Second International Congress of Microbiology, July 14 – 16, 2012, Ardabil - Iran.

Text - Published Version

Official URL: http://congress.arums.ac.ir/index.php/IICM/5/sched...


Survey of Microbial Prevalence and Antibiotic Resistance in Cystic Fibrosis Patients in Tehran

English Abstract

Background & Objectives: Cystic fibrosis is the most common lethal genetic disease in white populations. Cystic fibrosis is caused by a mutation in a gene that encodes cystic fibrosis transmembrane conductance regulator (CFTR) protein,which is expressed in many epithelial cells and blood cells. Respiratory tract of Cystic fibrosis patients can be described as natural environments harbouring persisting microbs such as Pseudomonas aeruginosa, Burkholderia cepacia, Achromobacter xylosoxidans, and Stenotrophomonas maltophilia, S. aureus, Streptococcus pneumoniae and Haemophilus influenzae.Without antibiotic treatment the patients with CF are at risk of early infection and inflammation becoming established and ultimately progressing to fatal respiratory failure. The goal of this study was to examine the current microbiology and susceptibility of organisms isolated from Cystic fibrosis patients. Methods: Sputum samples cultured on Blood agar,B. cepacia selective agar (BCSA), MacConkey's Agar, Cetrimide agar and Chocolate agar. Isolates was detected by conventional microbial methods. Then antibiotic susceptibility of isolates detected by Kirby-Bauer disk diffusion methods and serial microdilution (MIC) methods. Results: In this study 24 sputum samples of cystic fibrosis patients examined.18 patients infectd with bacteria as Enterococcus faecium (n=1), Enterobacter agglomerans(n=1), Enterobacter cloacae(n=2), E.coli (n=2), Pseudomonas aeruginosa (n=1), Acinetobacter johnsonii (n=1), Acinetobacter lwoffii (n=1), Acinetobacter baumannii(n=1), Staphylococcus aureus(n=1), Staphylococcus lugdunensis(n=1), Staphylococcus schleiferi(n=1), Stenotrophomonas maltophilia (n=1), Klebsiella pneumoniae (n=2), Moraxella osloensis (n=1), Moraxella atlantae(n=1). In some patients more than one bacteria isolated. E.faecium is the most resistant to all group of antibiotics.The most antibiotic resistancy is relate to cephalosporins, Penicillin and Nitrofurantoin and the least of antibiotic resistancy is relate to meropenem and imipenem. Conclusion: Our study showed that cystic fibrosis patients in Tehran are in subject to various bacteria of gram-positive and gram-negative.Current antibiotics are not usefull in eradication of bacteria involved in cystic fibrosis patients,so usage of newer antibiotics or another technics are essential.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :رضا اکبری
کلیدواژه ها (انگلیسی):Microbial Prevalence ; Antibiotic Resistance ; Cystic Fibrosis
Subjects:QW Microbiology and Immunology
WF Respiratory System
Divisions:Vice Chancellor for Research and Technology > Deputy for Research and Technology management and Medical Information > University of Management Conferences and Congresses
ID Code:4838
Deposited By: MS Soghra Golmaghani
Deposited On:01 Aug 1392 14:26
Last Modified:01 Aug 1392 14:26

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