title

الگوی حساسیت آنتی بیوتیکی سویه های اشریشیا کولی عامل اسهال جدا شده از کودکان بیمار

رادکریم, سلمان and علی, عارف (1391) الگوی حساسیت آنتی بیوتیکی سویه های اشریشیا کولی عامل اسهال جدا شده از کودکان بیمار. در: The 13th Iranian & The Second International Congress of Microbiology, July 14 – 16, 2012, Ardabil - Iran.

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Title

Antibiotic Susceptibility Patterns of Diarrheagenic Escherichia coli Strains Isolated from Diarrhoeic Children

English Abstract

Background & Objectives: Diarrheagenic Escherichia coli (E.coli) is an important cause of endemic and epidemic diarrhoea worldwide. Diarrheagenic E.coli belongs to different categories of pathotypes which are classified based on their distinct clinical features, virulence mechanisms and serotypes.The emergence of drug resistance among diarrhoeagenic E.coli in the paediatric population is an important cause of morbidity and mortality in developing countries. Antimicrobial resistance is a global problem and the emergence of multidrug resistance will hinder therapeutic options, hence monitoring resistance is of paramount importance. In our study we have embarked upon a massive drive to collect as many samples as possible. Methods: In this study we are presenting the results obtained for 500 diarrhoeic samples collected from two hospitals in Delhi from children below 5 years of age. These were screened for E.coli using standard microbiological procedures. Antibiotic susceptibility testing was determined by Kirby-Baeur disc–diffusion technique as described by Clinical and Laboratory Standard Institute (CLSI, formerly the NCCLS). Results: E.coli resistance against most commonly used antibiotics is on the rise. Among 420 confirmed E.coli isolates tested for antibiotic resistant pattern 90 % were resistant to Cefpodoxime/Clavulanic acid, 60 % to Aztreonam and Kanamycin, 65% to Colistin and Ceftazidime, 70 % to Cephotaxime, 75 % to Amikacin, 50 % to Nitrofurantoin and Amoxyclav, 85 % were resistant to Cefopodoxime, 30 % to Ceftazidime/Clavulanic acid, and 0 % to Imipenem. Conclusion: These findings confirm the significant increase in the incidence of antimicrobial resistance in E.coli. This may be due widespread antibiotic usage that may be exerting a selective pressure that acts as a driving force in the development of antibiotic resistance. The indiscriminate use and misuse of antibiotics should therefore be discouraged.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :سلمان رادکریم
کلیدواژه ها (انگلیسی):Antibiotic Resistance ; Escherichia coli ; Disk Diffusion Test
Subjects:QW Microbiology and Immunology
WI Digestive System
WS Pediatrics
Divisions:Vice Chancellor for Research and Technology > Deputy for Research and Technology management and Medical Information > University of Management Conferences and Congresses
ID Code:4857
Deposited By: MS Soghra Golmaghani
Deposited On:05 Aug 1392 10:27
Last Modified:05 Aug 1392 10:27

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