آنزیم های متالوبتالاکتامازو تعیین میزان مقاومت به آنتی بیوتیک های سفتازیدیم و ایمی پنم سویه های پسودوموناس آئروزینوزای مقاوم جدا شده از تجهیزات پزشکی

عنوان انگليسی

Metallo-β-Lactamases Enzymes and Determine Ceftazidime and Imipenem Resistant Pseudomonas Aeruginosa Isolated from ICU Equipment

خلاصه انگلیسی

Background & Objectives: Pseudomonas aeruginosa is the most resistant bacteria that can cause different disease in humans. One way to create resistance to Carbapenems in Pseudomonas aeruginosa is MBLs enzyme produced. The aim of this study was to determine of imipenem, ceftazidime-resistant pseudomonas aeruginosa and the presence of metallo- β-lactamases (MBLs) in resistant isolates. Methods: The antimicrobial resistance patterns of 50 Pseudomonas aeruginosa isolated from ICU equipment in Shahid Beheshti Hospital ,Babol were determined from the disk diffusion (Kirby-Bauer) methods and beta lactamase producing by double disc diffusion methods. Results: The most resistant was to cefepime. From a total of 50 isolates Pseudomonas aeruginosa 54% were found to be resistant to imipenem and 92% to ceftazidime. 10% of imipenem-resistant strains have beta lactamase enzymes. All isolates MBLs producing were resistant to cefepime, ceftriaxone and ceftazidime. Conclusion: According to our results, resistance to antibiotics in the country, including ceftazidime and Carbapenems is a serious problem, rapid identification of them and use of infections the appropriate infection control measures are necessary to prevent futher spread of by these organisms.

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