اثر تجویز تک دوز متیل سولفونیل متان بر استرس اکسیداتیو ناشی از فعالیت فیزیکی حاد ناتوان کننده

نخستین روحی, بابک and نیکنام, زهرا and واعظی, نسرین and محمدی, پرهام سعداله and بهلولی, شهاب (1392) اثر تجویز تک دوز متیل سولفونیل متان بر استرس اکسیداتیو ناشی از فعالیت فیزیکی حاد ناتوان کننده. Iranian Journal of Pharmaceutical Research ــ 12 (4). pp. 845-853. شاپا 1735-0328

Text - Published Version

Official URL: http://ijpr.sbmu.ac.ir/?_action=articleInfo&articl...


Effect of Single Dose Administration of Methylsulfonylmethane on Oxidative Stress Following Acute Exhaustive Exercise

English Abstract

Methylsulfonylmethane (MSM) is a sulfur-containing compound commonly found in diet and known to reduce oxidative stress. This trial was conducted to determine whether single dose supplementation with MSM attenuates post-exercise oxidative stress in healthy untrained young men. Sixteen untrained men volunteered for this study. Participants were randomized in a double-blind placebo-controlled fashion into 2 groups: Methylsulfonylmethane (MSM) (n = 8) and placebo (n = 8). The participants took supplementation or placebo before running on treadmill for 45 min at 75% VO2max. The MSM supplementation was prepared in water as 100 mg/kg body weight. The placebo group received water. Serum Malondealdehyde (MDA), uric acid, bilirubin, protein carbonyl (PC) and plasma vitamin E levels were determined as the markers of oxidative stress. Plasma GSH (reduced Glutathione) and total antioxidant capacity (TAC) were measured as markers of plasma antioxidant system. MSM supplementation successfully lowered serum PC 2 and 24 h after exercise. Plasma TAC in MSM group was higher at 24 h after exercise. Serum level of uric acid and bilirubin were significantly low immediately after exercise in MSM supplemented group. There was no significant difference between groups in terms of plasma GSH level. These results complement earlier studies showing anti-oxidant effect of MSM and suggest that single dose oral supplementation with MSM lowers exercise induced oxidative stress in healthy untrained young men, but is not adequate to significantly affect plasma GSH level.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :بابک نخستین روحی
نویسنده :زهرا نیکنام
نویسنده :نسرین واعظی
نویسنده :پرهام سعداله محمدی
نویسنده مسئول :شهاب بهلولی
Additional Information:Impact Factor (2012): 0.540 Abstracting and Indexing: ISI Web of Science (Science Citation Index Expanded) /Chemical Abstracts / Index Copernicus / IMEMR / DOAJ / Biosis Previews / Journal Citation Reports / IPA / EMBASE / Scopus / EMRmedex / EMRO / Iran medex / Open J-Gate / Scientific Information Database (SID) / EBSCO / ISC / Iran Journal / Google Scholar
Uncontrolled Keywords:متیل سولفونیل متان، آنتی اکسیدان، کربنیلاسیون پروتئین، گلوتاتیون، ظرفیت آنتی اکسیدان تام، مالون دی آلدهید
کلیدواژه ها (انگلیسی):MSM; Antioxidant; Protein carbonylation; GSH; Uric acid; Bilirubin; TAC; MDA
Subjects:QT physiology
QV pharmacology
Divisions:School of Pharmacy > Department of Pharmacology
ID Code:4921
Deposited By: Dr Shahab Bohlooli
Deposited On:27 Aug 1392 11:54
Last Modified:12 Dec 1397 13:37

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