title

ارزیابی ژنوتیپ های ویروس پاپیلومای انسانی در سرطان سلول سنگفرشی مری

یحیی پور, یوسف and منوری, سید حمیدرضا (1391) ارزیابی ژنوتیپ های ویروس پاپیلومای انسانی در سرطان سلول سنگفرشی مری. در: The 13th Iranian & The Second International Congress of Microbiology, July 14 – 16, 2012, Ardabil - Iran.

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Title

Genotypes Evaluation of Human Papillomavirus in Esophageal Squamous Cell Carcinoma

English Abstract

Background & Objectives: Human papillomavirus (HPV) has been associated with several disorders of the genital tract, skin and oropharynx. The aims of this study were to evaluate the prevalence of HPV infection in Esophagus Squamous Cell Carcinoma (ESCC) in Mazandran (North of Iran) and to identify the prevalence of some high and low risk Human papillomaviruses (HR & LR-HPV) genotypes. Methods: From 2004 to 2011, we examined formalin-fixed and paraffin-embedded ESCC specimens from Shahid Beheshti Hospital in Babol, Mazandaran, Iran. All the patients live in Mazandaran province, a region in Asian belt of esophagus cancer. 135 samples of ESCC tested for HPV-DNA and HPV genotypes by Real time PCR HPV Genotyping. Results: Overall HPV-DNA positivity was detected in 25.2% of the ESCC samples. The prevalence of HR-HPV and LR-HPV infection among HPV positive samples was 44.1% with a specific prevalence of HPV 11, 6, 45, of 14.3%, 11.8% and 11.8%, respectively; 5.9% for every type of 31, 33, 39, 52, 56 and 2.9% of ESCC patient infected with every HPV genotypes of 16, 35 and 59. Multiple infections with any HPV types were 17.6% of HPV L1 positive samples. Conclusion: In spite of large studies that implicated HPV plays an important role in ESCC, we found that HPV does not an important risk factor for ESCC in our patients. However this findings needs to clarify in a study with bigger sample size.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :یوسف یحیی پور
کلیدواژه ها (انگلیسی):Papillomavirus ; Carcinoma ; Genotyp
Subjects:QW Microbiology and Immunology
QZ Pathology
WO Surgery
Divisions:Vice Chancellor for Research and Technology > Deputy for Research and Technology management and Medical Information > University of Management Conferences and Congresses
ID Code:4929
Deposited By: MS Soghra Golmaghani
Deposited On:29 Aug 1392 09:06
Last Modified:19 Sep 1392 08:36

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